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Our research is broadly focused on the role of dendritic cells (DCs) in the initiation and propagation of HIV-1 replication. Since dendritic cells are believed to be the first immune competent cells to encounter virus in the genital mucosa, a thorough understanding of the HIV-DC interactions is of paramount importance. DCs can capture virus particles independently of CD4 and co-receptor complexes, and retain them in an infectious state for an extended period of time. These virus-bearing DCs may then facilitate a more efficient spread of virus to replication-permissive CD4+ T cells. Our recent work has identified a novel glycosphingolipid dependent mechanism of virus attachment to DCs. The fate of the virus particle post-attachment in DCs remains unclear. Virion trafficking within the DC bypasses conventional endocytic organelles, i.e., endosomes and lysosomes. Virus localization within this novel vesicular compartment not only has the potential to protect the invading HIV from being degraded, but also creates a latent reservoir of virus, which could present a major challenge for eradication by antiretroviral therapy. Furthermore, the mechanism of subsequent return of infectious virus particles to the cell surface and the method of subsequent transmission to T cells remains unclear. Current studies utilizing biochemical and microscopic approaches are underway to monitor HIV-1 trafficking and localization in the DC and its subsequent transfer to T cells.
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论文共 87 篇作者统计合作学者相似作者
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CELLSno. 5 (2024): 432
Seth A Ament, Rianne R Campbell, Mary Kay Lobo, Joseph P Receveur, Kriti Agrawal, Alejandra Borjabad, Siddappa N Byrareddy,Linda Chang, Declan Clarke, Prashant Emani,Dana Gabuzda, Kyle J Gaulton,
Molecular psychiatrypp.1-12, (2024)
Teresa A. Colvin,Vladimir L. Gabai,Jianlin Gong,Stuart K. Calderwood, Hu Li,Suryaram Gummuluru,Olga N. Matchuk, Svetlana G. Smirnova, Nina V. Orlova,Irina A. Zamulaeva, Mikel Garcia-Marcos,Xiaokai Li,
crossref(2023)
Mai Komori,Amber L Morey, Andrés A Quiñones-Molina, Josiane Fofana, Luis Romero, Elizabeth Peters,Kenta Matsuda,Suryaram Gummuluru,Jonathan F Smith,Wataru Akahata,Hisashi Akiyama
bioRxiv : the preprint server for biology (2023)
Getulio Pereira de Oliveira Junior,Joshua A Welsh,Brandy Pinckney,Cintia C Palu,Shulin Lu,Alan Zimmerman,Raquel Hora Barbosa,Parul Sahu, Maeesha Noshin,Suryaram Gummuluru,John Tigges, Jennifer Clare Jones,
Journal of extracellular biologyno. 11 (2023): n/a-n/a
RuthMabel Boytz,Mikolaj Slabicki, Sita Ramaswamy,J. J. Patten,Charles Zou,Chengcheng Meng,Brett L. Hurst, Jinhua Wang,Radoslaw P. Nowak,Priscilla L. Yang,Martin Sattler,Richard M. Stone,
bioRxiv : the preprint server for biology (2022)
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