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Cell to cell communication and signal transduction are crucial for many of biological processes of unicellular and multicellular organisms and largely mediated by proteins decorating the cell surface. About 10-20% of surface protein is attached to the plasma membrane by glycosylphosphatidylinositol (GPI) anchors. A GPI anchor is a glycolipid structure containing phosphoethanolamine, a glycan core and a phosphatidylinositol tail. GPI-anchored proteins play roles in numerous signaling pathways including Notch, shh, BMP, FGF, Wnt, GDNF and JAK-STAT, which are critical during development and adulthood. Despite the conservation, abundance and importance of GPI anchorage, the mechanisms regulating GPI-anchored proteins and their downstream signaling are largely unknown. Currently, a family of recently identified glycerophosphodiester phosphodiesterase (GDE) enzymes is the only known regulator of surface GPI-anchored proteins in vertebrates. Phenotypic analyses of GDE null animals have begun to reveal critical roles of GPI-anchored proteins in multiple processes including neurogenesis, gliogenesis, synapse maturation and neurodegeneration.
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bioRxiv : the preprint server for biology (2024)
bioRxiv : the preprint server for biology (2024)
CIRCULATION RESEARCHno. Suppl_1 (2023)
JOURNAL OF FUNCTIONAL FOODS (2023): 105681
CIRCULATION RESEARCHno. Suppl_1 (2023)
BioPsychoSocial medicineno. 1 (2023): 1-6
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