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个人简介
I have focused my research on the clinical aspects of type 2 diabetes particularly as regards investigating novel agents and other strategies for the prevention and treatment of diabetes and pre-diabetes. As part of the Center for Metabolic Research at the VA Hospital, I participate in several studies which utilize the hyperinsulinemic and hyperglycemic clamp studies and muscle and fat biopsies to evaluate insulin sensitivity and insulin secretion in both non-diabetic and diabetic subjects, before and after various therapeutic interventions. I am currently a Co-investigator in the NIH/NIDDK sponsored multicenter Diabetes Prevention Program Outcome Study, “DPPOS”. This study is a continuation of the earlier landmark diabetes study that showed the intensive lifestyle modification with diet/exercise or intervention with metformin significantly decreased the incidence of diabetes in patients with pre-diabetes. Currently, the study is evaluating the incidence and progression of diabetic complications, carotid intimal media thickness, abdominal fat distribution and cardiovascular disease in these pre-diabetes and early diabetic subjects. I am also a Co-Investigator on the NIH sponsored GRADE study (Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study) which is a randomized clinical trial in patients with recent-onset (<5 years duration) type 2 diabetes and will compare the metabolic effects of four common anti-diabetic drugs when combined with metformin. I am also the PI on several industry sponsored grants, evaluating the efficacy and safety of medications for the treatment of type 2 diabetes and its cardiovascular complications.
研究兴趣
论文共 256 篇作者统计合作学者相似作者
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Diabetes Careno. 4 (2024): 580-588
Jennifer B Green,Brendan M Everett, Alokananda Ghosh,Naji Younes,Heidi Krause-Steinrauf,Joshua Barzilay,Cyrus Desouza,Silvio E Inzucchi,Yashashwi Pokharel,David Schade, Alexandra Scrymgeour,Meng H Tan,
Circulationno. 13 (2024): 993-1003
Alin Alshaheri Durazo,Alexandra J. Weigand,Katherine J. Bangen, Rachel Membreno,Sunder Mudaliar,Kelsey R. Thomas
JOURNAL OF ALZHEIMERS DISEASEno. 1 (2024): 219-228
Diabetes, obesity & metabolismno. 7 (2023): 1985-1994
JAMA internal medicineno. 7 (2023): 705-714
Journal of the Indian Institute of Scienceno. 1 (2023): 123-133
Rachel Membreno Almendares,Katherine J Bangen,Monica T Ly,Kayla S Walker,Sunder Mudaliar,Kelsey R Thomas
Journal of the International Neuropsychological Societyno. s1 (2023): 104-105
JAMA Internal Medicineno. 7 (2023): 705-705
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