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Bio
My research is focused on the genetics of Cryptosporidium parvum, a protozoan parasite that causes diarrheal disease (Cryptosporidiosis) in humans and animals. Cryptosporidium is the second leading pathogen after rotavirus to cause life-threatening diarrhea and developmental stunting in young children. It is also an opportunistic pathogen and causes severe disease in HIV/AIDS patients and organ transplant recipients. In addition to being a human pathogen, C. parvum is a common ruminant pathogen, that causes huge economic losses to the agricultural industry. Currently, there are no effective drugs or vaccines to treat or prevent Cryptosporidiosis. The Cryptosporidium field has been lagging behind due to lack of continuous culture system, poor animal models, and lack of genetic tools (until recently!). I have established a powerful technology to genetically manipulate this important pathogen (Vinayak et al, Nature 2017). Taking advantage of transgenic C. parvum parasite lines, I have developed a robust mouse model for testing the efficacy of anti-cryptosporidial compounds (Manjunatha, Vinayak et al 2017, Nature). The transformation of C. parvum into a genetically tractable organism will enhance our understanding of the basic biology of the parasite, and accelerate drug discovery and vaccine development efforts.
Research Interests
Papers共 35 篇Author StatisticsCo-AuthorSimilar Experts
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Wes van Voorhis,Joyce Siwila,Jessica C. Kissinger, Natalia Bayona Vásquez,Guy Robinson,Rodrigo Baptista,Asis Khan,Amandine Guérin,Yi-Wei Chang, Zannatun Noor,N. Bishara Marzook,Sumiti Vinayak,
Trends in Parasitologyno. 6 (2024): 431-438
Cell Reportsno. 6 (2024): 114263-114263
BMJ global healthno. 8 (2023)
Derek J. Pinto,Sumiti Vinayak
Current Clinical Microbiology Reportsno. 2 (2021): 62-67
Sumiti Vinayak,Rajiv S Jumani,Peter Miller,Muhammad M Hasan,Briana I McLeod,Jayesh Tandel,Erin E Stebbins, Jose E Teixeira,Julien Borrel,Arthur Gonse,Mingliang Zhang, Xianshui Yu,
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