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Research Interests
The research in the Houser laboratory is focused on those processes that maintain the electrical and contractile properties of the normal heart and the defects in these processes that lead to electrical instability (arrhythmias and sudden death) and poor cardiac pump performance congestive heart failure). We are currently continuing our studies of the determinants of cellular electrical and mechanical defects in diseased cardiac myocytes. In addition, we are exploring the idea that a major factor that determines the overall state of cardiac myocyte function is a balance between new myocyte formation (cardiac regeneration) and programmed myocyte death (apoptosis).
Our cell physiology studies are exploring the idea that activation of Ca2+ dependent signaling pathways (mainly through CAMKII) regulate Ca2+ handling proteins in diseased myocytes. We have developed techniques in live cells to track Ca2+ dependent activation of NFAT and are characterizing the associated alterations in cell function. These studies are being performed in collaboration with Dr. Jeffrey Molkentin at the University of Cincinnati. The second and third areas of new research are centered on the new idea that there is myocyte turnover in the adult heart. Therefore, we are studying the factors that regulate cell death (mainly through apoptosis, with Dr. Richard Kitsis) and new myocyte formation (via cardiac progenitor cells, with Drs Annarosa Leri and Piero Anversa). We have identified cardiac stem/progenitor cells in feline and human hearts and plan for a rapid expansion of this novel (and controversial) area. We will specifically explore the hypothesis that hypertrophy in response to pressure overload involves new myocyte formation in addition to enlargement of terminally differentiated myocytes. Our newest data shows that expression of T-type Ca2+ channels is linked to differentiation of cardiac stem cells into new cardiac myocytes. Ca2+ influx through these channels also appears to be linked to proliferation of new myocytes.
The research in the Houser laboratory is focused on those processes that maintain the electrical and contractile properties of the normal heart and the defects in these processes that lead to electrical instability (arrhythmias and sudden death) and poor cardiac pump performance congestive heart failure). We are currently continuing our studies of the determinants of cellular electrical and mechanical defects in diseased cardiac myocytes. In addition, we are exploring the idea that a major factor that determines the overall state of cardiac myocyte function is a balance between new myocyte formation (cardiac regeneration) and programmed myocyte death (apoptosis).
Our cell physiology studies are exploring the idea that activation of Ca2+ dependent signaling pathways (mainly through CAMKII) regulate Ca2+ handling proteins in diseased myocytes. We have developed techniques in live cells to track Ca2+ dependent activation of NFAT and are characterizing the associated alterations in cell function. These studies are being performed in collaboration with Dr. Jeffrey Molkentin at the University of Cincinnati. The second and third areas of new research are centered on the new idea that there is myocyte turnover in the adult heart. Therefore, we are studying the factors that regulate cell death (mainly through apoptosis, with Dr. Richard Kitsis) and new myocyte formation (via cardiac progenitor cells, with Drs Annarosa Leri and Piero Anversa). We have identified cardiac stem/progenitor cells in feline and human hearts and plan for a rapid expansion of this novel (and controversial) area. We will specifically explore the hypothesis that hypertrophy in response to pressure overload involves new myocyte formation in addition to enlargement of terminally differentiated myocytes. Our newest data shows that expression of T-type Ca2+ channels is linked to differentiation of cardiac stem cells into new cardiac myocytes. Ca2+ influx through these channels also appears to be linked to proliferation of new myocytes.
Research Interests
Papers共 538 篇Author StatisticsCo-AuthorSimilar Experts
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Circulationno. 12 (2024): e964-e985
Yijun Yang, Silvia Anahi Valdés-Rives,Qing Liu,Yuzhe Li,Jun Tan,Yinfei Tan,Christian A Koch,Yuan Rong,Steven R. Houser,Shuanzeng Wei,Kathy Q Cai,Sheue-yann Cheng,
bioRxiv the preprint server for biology (2024)
Circulationno. 20 (2024): 1598-1610
Circulation researchno. 2 (2023): 120-137
American Journal of Physiology-heart and Circulatory Physiologyno. 4 (2023): H443-H460
American journal of physiology. Heart and circulatory physiologyno. 4 (2023): H702-H719
CIRCULATION RESEARCHno. Suppl_1 (2023)
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