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Phospholipids are the building blocks of biological membranes which enable cells to separate biochemical pathways, establish specialized functions that can respond when appropriate, and adapt to constantly fluctuating metabolic conditions. My laboratory’s research focus is on the underappreciated contribution of the mitochondrion to cellular phospholipid metabolism. In addition to being the sole producer of the canonical mitochondrial lipid, cardiolipin (CL), the mitochondrion hosts one of the two major pathways in a cell for the production of phosphatidylethanolamine (PE). Ablation of the mitochondrial capacity to synthesize either CL or PE is embryonically lethal in mice. Moreover, in the yeast Saccharomyces cerevisiae, the combined absence of CL and PE is synthetically lethal. Using a combination of yeast and mammalian cell culture models, my lab currently has three major ongoing projects centered on different aspects of mitochondrial phospholipid metabolism in health and disease.
Phospholipids are the building blocks of biological membranes which enable cells to separate biochemical pathways, establish specialized functions that can respond when appropriate, and adapt to constantly fluctuating metabolic conditions. My laboratory’s research focus is on the underappreciated contribution of the mitochondrion to cellular phospholipid metabolism. In addition to being the sole producer of the canonical mitochondrial lipid, cardiolipin (CL), the mitochondrion hosts one of the two major pathways in a cell for the production of phosphatidylethanolamine (PE). Ablation of the mitochondrial capacity to synthesize either CL or PE is embryonically lethal in mice. Moreover, in the yeast Saccharomyces cerevisiae, the combined absence of CL and PE is synthetically lethal. Using a combination of yeast and mammalian cell culture models, my lab currently has three major ongoing projects centered on different aspects of mitochondrial phospholipid metabolism in health and disease.
Research Interests
Papers共 109 篇Author StatisticsCo-AuthorSimilar Experts
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Olivia Sniezek Carney, Kodi William Harris, Yvonne Wohlfarter, Kyuna Lee, Grant Butschek,Arianna Anzmann,Steven M Claypool, Anne Hamacher-Brady,Markus Keller,Hilary J Vernon
bioRxiv : the preprint server for biology (2024)
Brenita C Jenkins,Kit Neikirk,Prasanna Katti,Steven M Claypool,Annet Kirabo,Melanie R McReynolds,Antentor Hinton
Trends in biochemical sciencesno. 4 (2024): 346-360
Antentor Hinton,Steven M Claypool,Kit Neikirk, Nanami Senoo,Celestine N Wanjalla,Annet Kirabo,Clintoria R Williams
Circulation researchno. 2 (2024): 372-396
Nanami Senoo,Dinesh K Chinthapalli,Matthew G Baile, Vinaya K Golla,Bodhisattwa Saha, Abraham O Oluwole,Oluwaseun B Ogunbona,James A Saba, Teona Munteanu, Yllka Valdez,Kevin Whited, Macie S Sheridan,
The EMBO journal (2024)
bioRxiv : the preprint server for biology (2024)
Nanami Senoo,Dinesh K Chinthapalli,Matthew G Baile, Vinaya K Golla,Bodhisattwa Saha,Oluwaseun B Ogunbona,James A Saba, Teona Munteanu, Yllka Valdez,Kevin Whited,Dror Chorev,Nathan N Alder,
bioRxiv : the preprint server for biology (2023)
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