Dr. Jones’ research program is firmly entrenched in genome science to better understand the complete mutational landscape of cancers. His primary aim is to help uncover the diversity of genetic and genomic events that accrue to give rise to cancers, and which also encourage their evolution and maintain their progression. His laboratory extensively analyzes Next Generation genome and transcriptome data to achieve these goals. Dr. Jones has developed a number of novel computational approaches and methodologies to this end and has provided numerous insights into cancer dynamics, potential biomarkers and therapeutic targets. A significant part of Dr. Jones research program relates to developing more precise cancer treatments by exploiting an individual’s specific cancer genome profile. His research has identified numerous epigenetic targets that have the potential to be modulated in such a way as to reverse the effects of mutations within a cancer genome. Using computational approaches, his research team has identified and refined compounds that modify epigenetic programs in cancer. His laboratory also acts as a data analysis centre for the Canadian Epigenetics, Environment and Health Research Consortium (CEEHRC).