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Bio
Dr. Steven D. Douglas has been investigating cellular immune mechanisms and monocyte-macrophages. His laboratory is funded by a longstanding R01,Tachykinins Mononuclear Phagocytes and HIV-1 Infection. He is the PI for a U01, Anti-HIV Neuroimmunomodulatory Therapy with Neurokinin-1 Antagonists (NIMH) (through 2014), which encompasses three Projects (including a clinical trial) and two Cores (including Pharmacology and Biostatistics). He and his group investigate the interaction between neuropeptides, monocyte-macrophages and HIV. He is the Principal Investigator for the Philadelphia International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Unit, which includes a Clinical Research Site at CHOP, Clinical Research Site at the Adult Unit at the Hospital of the University of Pennsylvania, and two Satellites (Hospital of the University of Pennsylvania and Pennsylvania Hospital)(NIAID). Douglas’ laboratory is the central immunology laboratory for the IMPAACT Network, and a specialty immunology laboratory. He is also the PI for the Adolescent Trial Network (NICHD). These networks are state-of-the-art therapeutic trials for adult and pediatric HIV/AIDS throughout the world. The Douglas laboratory does basic, translational, and clinical research.
Dr. Douglas' ongoing research program involves molecular and cellular immunologic studies of substance P and its receptor, Neurokinin-1 in monocyte-macrophages. He discovered the truncated from of NK1-R in human cells and demonstrated that SP antagonists block HIV through CCR5 and he has applied as NK1R antagonists novel HIV therapy. He has also demonstrated up-regulation of substance P by HIV. His laboratory is actively involved in research in cellular immunology and its relationship to the immunopathogenesis of HIV. Dr. Douglas has extensive experience in cellular and humoral immunologic studies, including studies of AIDS infection and of primary immunodeficiencies. He has recently instigated studies involving psychosocial and psychiatric interactions with the immune and nervous systems. Ongoing studies have demonstrated associations between substance P, impaired natural killer cell activity and depression in HIV-infected individuals.
Early in his career, Dr. Douglas discovered pokeweed mitogen as a lymphocyte stimulator and developed tests to diagnose immune deficiency diseases. He developed methods for isolation-differentiation of blood monocytes into macrophages and showed the role of macrophages in HIV. He detected SP-preferring receptor, neurokinin-1 (NK1R), in monocytes, and that SP antagonists inhibit HIV. He is testing NK1R antagonists as therapy for HIV patients.
Dr. Douglas has been President, Society for Leukocyte Biology. He has chaired committees for the VA, FDA (Blood Products Advisory Committee); and Chair NIH-CSR (AIDS Immunology Pathogenesis Study Section). He is the Founding Editor-in-Chief of Clinical and Diagnostic Laboratory Immunology, American Society Microbiology. He was the Recipient of Abbott Immunology, Neter, Conason, and Redway Awards. He is a Member ASCI, American Academy Microbiology, Honorary Life Member Society for Leukocyte Biology, Fellow AAAS.
Research Interests
Papers共 525 篇Author StatisticsCo-AuthorSimilar Experts
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Jeffrey S. Barrett, Brenden Canning,Joseph Coulson,Erin Dombrowsky,Steven D. Douglas,Tung M. Fong,Christa Y. Heyward,Susan E. Leeman, Pranela Remeshwar
IUPHAR/BPS guide to pharmacology CITEno. 1 (2023)
British Journal of Pharmacologyno. S2 (2023): S23-S144
Cecile M. Denis,Tiffany Dominique,Peter Smith,Danielle Fiore,Yi-Chien Ku, Angus Culhane,Debora Dunbar,Dana Brown, Menvekeh Daramay,Chelsea Voytek,Knashawn H. Morales,Michael B. Blank,
Jeffrey S. Barrett, Brenden Canning,Joseph Coulson,Erin Dombrowsky,Steven D. Douglas,Tung M. Fong,Christa Y. Heyward,Susan E. Leeman, Pranela Remeshwar
IUPHAR/BPS Guide to Pharmacology CITEno. 4 (2019)
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Author Statistics
#Papers: 524
#Citation: 18509
H-Index: 70
G-Index: 70
Sociability: 7
Diversity: 4
Activity: 3
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