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Dr. Clarke has established the paradigm that biological aging is no less than war waged between chemistry and biology. Chemistry represents the spontaneous reactions that degrade biomolecules and biology represents the response of the organism to limit the chemical damage. His laboratory discovered and has characterized a novel pathway that has demonstrated that macromolecular repair is not just for DNA, but for proteins as well! These studies have not only given us a new window to view protein “life” but also suggest that the biological aging process may be closely linked to how well one can keep polypeptides free of spontaneous damage. He has gone on to show that the enzymatic recognition of damage is not limited to DNA and proteins but is a more general response of cells to molecular damage, particularly of crucial metabolites such as cis -aconitate and S -adenosylmethionine. His laboratory has also been in the forefront of identifying new types of methyltransferases that are involved in cellular signaling reactions. His laboratory has discovered enzymes that modify signaling proteins by methylation reactions at C-terminal isoprenylated cysteine residues and leucine residues, as well the first member of the family of protein arginine methyltransferases involved in multiple cellular processes including DNA repair, gene expression, protein translocation, and signaling.
Dr. Clarke has established the paradigm that biological aging is no less than war waged between chemistry and biology. Chemistry represents the spontaneous reactions that degrade biomolecules and biology represents the response of the organism to limit the chemical damage. His laboratory discovered and has characterized a novel pathway that has demonstrated that macromolecular repair is not just for DNA, but for proteins as well! These studies have not only given us a new window to view protein “life” but also suggest that the biological aging process may be closely linked to how well one can keep polypeptides free of spontaneous damage. He has gone on to show that the enzymatic recognition of damage is not limited to DNA and proteins but is a more general response of cells to molecular damage, particularly of crucial metabolites such as cis -aconitate and S -adenosylmethionine. His laboratory has also been in the forefront of identifying new types of methyltransferases that are involved in cellular signaling reactions. His laboratory has discovered enzymes that modify signaling proteins by methylation reactions at C-terminal isoprenylated cysteine residues and leucine residues, as well the first member of the family of protein arginine methyltransferases involved in multiple cellular processes including DNA repair, gene expression, protein translocation, and signaling.
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PloS oneno. 5 (2023): e0285812-e0285812
AUTOIMMUNITYno. 1 (2023): 2282945-2282945
PLOS ONEno. 12 (2023): e0296291-e0296291
The Journal of biological chemistryno. 9 (2022): 102290-102290
Diabetesno. 9 (2022): 1979-1993
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