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个人简介
As Co-Director of the Gene Medicine Research Group my research is focused on the application of gene therapy technologies to provide therapeutic interventions for human disease. During my post-doctoral research at Oxford I was the first to demonstrate that gene transfer could correct the Cystic Fibrosis defect in transgenic mice. This led to an extensive pre-clinical and clinical programme of gene therapy. Products developed in the Gene Medicine Research Group have been evaluated in four gene therapy clinical trials. The most recent was a phase IIb clinical study involving 136 participants that showed a clinically relevant improvement in lung function in those receiving gene therapy over those receiving a placebo treatment. I am one of the founding principal investigators of the UK Cystic Fibrosis Gene Therapy Consortium, a rolling research programme to realise a gene therapy for cystic fibrosis. The consortium is comprised of three UK research groups who have conducted CF gene therapy clinical studies: the Gene Medicine Research Group, University of Oxford; the Centre for Molecular Medicine and Roslin Institute, University of Edinburgh; and, the Department of Gene Therapy, National Heart & Lung Institute, Imperial College London. Collectively we have been at the forefront of respiratory gene therapy for over 20 years.
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论文共 226 篇作者统计合作学者相似作者
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JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERYno. 6 (2023): A28-A28
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MOLECULAR THERAPYno. 4 (2023): 760-760
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Marina P. Cerezuela,Altar M. Munis,Yue Du, Catherine Chahrour,Helen Lockstone,John Broxholme,Benjamin Wright,Stephen C. Hyde,Deborah Gill
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Rosie J Munday,Tiziana Coradin,Rachael Nimmo,Yatish Lad,Stephen C Hyde, Kyriacos Mitrophanos,Deborah R Gill
Molecular Therapy - Methods & Clinical Development (2022): 239-252
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