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Bio
As Co-Director of the Gene Medicine Research Group my research is focused on the application of gene therapy technologies to provide therapeutic interventions for human disease. During my post-doctoral research at Oxford I was the first to demonstrate that gene transfer could correct the Cystic Fibrosis defect in transgenic mice. This led to an extensive pre-clinical and clinical programme of gene therapy. Products developed in the Gene Medicine Research Group have been evaluated in four gene therapy clinical trials. The most recent was a phase IIb clinical study involving 136 participants that showed a clinically relevant improvement in lung function in those receiving gene therapy over those receiving a placebo treatment. I am one of the founding principal investigators of the UK Cystic Fibrosis Gene Therapy Consortium, a rolling research programme to realise a gene therapy for cystic fibrosis. The consortium is comprised of three UK research groups who have conducted CF gene therapy clinical studies: the Gene Medicine Research Group, University of Oxford; the Centre for Molecular Medicine and Roslin Institute, University of Edinburgh; and, the Department of Gene Therapy, National Heart & Lung Institute, Imperial College London. Collectively we have been at the forefront of respiratory gene therapy for over 20 years.
Research Interests
Papers共 302 篇Author StatisticsCo-AuthorSimilar Experts
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JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERYno. 6 (2023): A28-A28
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Uta Griesenbach,Gerry McLachlan,A. Sinadinos, Cédric Cheminay,Joseph Ashour,Cuixiang Meng, E. Gonzalez-Abreu Castells, Richard H. Dean,Mariana Viegas,Alan Boyd,Jane C. Davies,Deborah R. Gill,
Journal of Cystic Fibrosis (2023): S33-S33
MOLECULAR THERAPYno. 4 (2023): 760-760
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C. McDougall, C. McLaughlin, E. Thornton, K. M. Miah, E. Castells, R. J. Dean, M. A. Viegas,S. C. Hyde, D. R. Gill,G. McLachlan
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P. Dickinson,L. Hyndman, G. Bartolomucci,A. Doherty, D. Gill,S. Hyde, E. Castells, R. Dean, K. Miah, M. Viegas,G. McLachlan,A. C. Boyd
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Marina P. Cerezuela,Altar M. Munis,Yue Du, Catherine Chahrour,Helen Lockstone,John Broxholme,Benjamin Wright,Stephen C. Hyde,Deborah Gill
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Patricia P Ogger, Minerva Garcia Martín,Christina Michalaki, Jie Zhou, Jonathan C Brown,Yue Du,Kamran M Miah,Omar Habib,Stephen C Hyde,Deborah R Gill,Wendy S Barclay,Cecilia Johansson
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