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个人简介
My work focuses on the underlying mechanisms that cause heart attacks, predominantly the causes of endothelial erosion, which is the trigger of ~30% of heart attacks. I have a particular focus on endothelial biology and the response of endothelial cells to elevated shear stress and endothelial dysfunction, to model the responses of the endothelium overlying stenotic atherosclerotic plaques. My interests include the molecular and cell components of mechanobiology and matrix biology. I work with a multidisciplinary team including clinicians, biologists, big data scientists, bioinformaticians and engineers, with collaborators across the globe.
Following a degree in microbiology and virology, I utilised my virology training to initially focus on the field of gene therapy, which culminated in a prestigious BHF intermediate fellowship on this topic and resulted in several high impact papers on targeting gene transfer vectors to the vasculature. Subsequently, I refocussed to concentrate on vascular biology and am now established as a vascular biologist, with particular expertise in biomechanics, endothelial dysfunction and molecular cell biology. I have also worked with colleagues on other aspects of vascular biology and have a good grasp of many aspects of smooth muscle cell, platelet and macrophage biology that influences atherosclerotic plaque formation and progression.
研究兴趣
论文共 83 篇作者统计合作学者相似作者
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Ilakya Selvarajan,Miika Kiema,Ru-Ting Huang,Jin Li,Jiayu Zhu,Petri Pölönen,Tiit Örd,Kadri Õunap,Mehvash Godiwala, Anna Kathryn Golebiewski,Aarthi Ravindran,Kiira Mäklin,
Arteriosclerosis, thrombosis, and vascular biologyno. 6 (2024): 1330-1345
Ramya Parasa,Retesh Bajaj,Alexander Broersen,Garg Mohil, Francesco Prati,Murat Cap, Nathan Angelo Lecaros Yap,Stephanie Grainger,Stephen White,Andreas Baumbach,Anthony Mathur,Hector Manel Garcia-Garcia,
Journal of the American College of Cardiologyno. 17 (2023): B275-B276
HEART (2023): A273-A273
Redox biology (2022): 102548-102548
REDOX BIOLOGY (2022)
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作者统计
#Papers: 83
#Citation: 2229
H-Index: 23
G-Index: 47
Sociability: 6
Diversity: 3
Activity: 17
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