基本信息
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职业迁徙
个人简介
My research focuses on PI3K and its role in the inflammatory process. Since the discovery of the prototypical PI3K in the late 1980’s, the family of PI3Ks and their lipid products (PI(3)P, PI(3,4)P2 and PI(3,4,5)P3 [PIP3]) have been the focus of intense investigation. Since the mid-1990’s I have used pharmacological and molecular approaches to identify the biochemical and physiological importance of PI3K-dependent-signalling pathways in the immune system. PI3Ks regulate important signalling cascade(s) involved in a plethora of cellular functional events such as survival, gene regulation, cell migration, growth and proliferation. My group is currently studying the activation of this signalling cascade during activation of the immune system. Specifically we are interested in the role that this molecule and its downstream biochemical and functional effectors play in key immune cells such as lymphocytes, macrophages, mast cells and eosinophils following activation by antigen, inflammatory mediators (e.g. chemokines and cytokines) and novel phospholipids immune regulators.
研究兴趣
论文共 282 篇作者统计合作学者相似作者
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Samuel Eisenstein, Brian A. Coakley, Karen Briley-Saebo,Ge Ma,Hui-ming Chen,Marcia Meseck,Stephen Ward,Celia Divino,Savio Woo,Shu-Hsia Chen,Ping-Ying Pan
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Samuel Eisenstein, Brian A. Coakley, Karen Briley-Saebo,Ge Ma,Hui-ming Chen, Marcia Meseck,Stephen Ward,Celia Divino,Savio Woo,Shu-Hsia Chen,Ping-Ying Pan
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FRONTIERS IN IMMUNOLOGY (2023): 1152140-1152140
Samuel Eisenstein,Brian A. Coakley, Karen Briley-Saebo,Ge Ma,Hui-ming Chen,Marcia Meseck,Stephen Ward,Celia Divino, Savio Woo,Shu-Hsia Chen,Ping-Ying Pan
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Cancersno. 23 (2022): 5738-5738
FEBS Lettersno. 21 (2022): 2721-2735
Adnan Al-Kaisy,David Pang,Jonathan Royds,Stefano Palmisani,Cormac Mullins, Joseph Palumbo,Alba Izquierdo-Barras, Karen Sanderson,Samuel Wesley,Omar Al-Kaisy,Stephen Ward,Thomas Yearwood
Neuromodulation: Technology at the Neural Interfaceno. 5 (2022)
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