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个人简介
Dr. Spiro's research is currently focused on responses to nitric oxide, a toxic free radical that is a by-product of normal metabolic processes in bacteria, as well as being a chemical defense synthesized by host phagocytic cells in response to infection by pathogenic microorganisms.
Research Interests
Nitric oxide (NO) is a water-soluble free-radical gas that is toxic in biological systems by virtue of its reactivity towards proteins, metal ions, lipids and DNA. Eukaryotic phagocytic cells exploit this toxicity by synthesizing NO as one of the arsenal of poisonous molecules that are used to kill invading pathogens. Successful intra-cellular pathogens (such as Salmonella and Mycobacterium species) are able to resist phagocyte killing mechanisms. There is increasing evidence that the ability to detoxify NO is required by some pathogens for survival inside host cells.
NO is also synthesized by Bacteria as an intermediate or by-product of normal respiratory processes. Specifically, nitrite can be used as an electron acceptor for anaerobic respiration by the denitrifying Bacteria, which reduce nitrite to NO, and also use NO as an electron acceptor, reducing it to nitrous oxide. The enteric Bacteria reduce nitrite to ammonia, but also catalyze the reduction of nitrite to NO, such that NO is made at a low concentration as a by-product of nitrite respiration.
研究兴趣
论文共 175 篇作者统计合作学者相似作者
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Journal of bacteriologyno. 4 (2024): e0008124-e0008124
Journal of Bacteriologyno. 4 (2023): e0002723-e0002723
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2021)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2020)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2020)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2018)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2017)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2017)
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作者统计
#Papers: 175
#Citation: 7692
H-Index: 46
G-Index: 87
Sociability: 5
Diversity: 2
Activity: 0
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