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Steve Cobbold is currently the Professor of Cellular Immunology at the Sir William Dunn School of Pathology, University of Oxford. He initially studied Biochemistry in Oxford, but in 1979 he moved to the Department of Pathology in Cambridge, England, to develop immunosuppressive monoclonal antibodies during his Ph.D. under the supervision of Herman Waldmann. This, and his subsequent post-doctoral work during the 1980s in Cambridge, led to the first demonstrations of tolerance induction to proteins and then organ grafts using CD4 monoclonal antibodies in adult rodents. As part of the Waldmann group, he was also actively involved in the development of CAMPATH monoclonal antibodies and together with Geoff Hale set up the analysis of a registry of in vitro and in vivo T cell depletion data for clinical bone marrow transplantation that became known as the CAMPATH Users Group. During this time he also developed statistical methods for the analysis of antibody clusters as used in the 3rd Human CD Antigen Workshop (1987) and for the classification of veterinary reagents, and in 1993 he organized the first Canine Leukocyte Antigen Workshop (CLAW). From December 1993 he worked for six months with Dr. Andrew Mellor at the National Institute for Medical Research in Mill Hill (London). Since that time, Prof. Cobbold has continued as a senior scientist within the Therapeutic Immunology Group at the Sir William Dunn School, where he continues to research the mechanisms of immune tolerance induction and maintenance with particular focus on the roles of regulatory T cells. He was also a scientific founder of TolerRx Inc., a company based in Boston to exploit CD4 and CD3 antibody induced tolerance therapies. Together with Geoff Hale and Peppy Rebello, he co-founded BioAnaLab Ltd., a company that performs contract research and diagnostic testing for the biopharmaceutical industry, which was successfully sold to Millipore in 2009. He has published more than 250 articles and patents on the therapeutic applications of monoclonal antibodies and the mechanisms of transplantation tolerance. He recently received a live, paired donation kidney transplant with CAMPATH induction - perhaps the ultimate clinical translation of his work.
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JOURNAL OF BIOLOGICAL CHEMISTRYno. 12 (2022): 102663-102663
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