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Bio
I studied for an undergraduate degree in Biochemistry and Microbiology at the University of Sheffield in 1997 during which time I undertook an undergraduate research project in X-ray crystallography, which fostered my strong interest in structural biology. Therefore, I continued in Sheffield for my PhD studies looking into the development of new anti-malarial and toxoplasmosis compounds through X-ray crystallography. After a brief postdoc in Sheffield I moved to Leeds in 2005 to learn electron microscopy (EM) and developed a keen interest in EM and its use for studying large membrane protein complexes. After the award of an MRC career development fellowship in 2010 I started my own group with a strong interest in combining different techniques to study the structure and function of a wide range of protein targets with the overall aim of driving structure based inhibitor design.
My group has worked on a range of systems from ion channels to developing new biosensors. Recent, major contributions to his field include: (i) The use of EM to drive inhibitor design for IGPD and the membrane bound bc1 complex, (ii) The first negative stain and cryo-EM reconstruction of a membrane protein extracted using styrene maleic acid lipid particles (SMALPs), which removes the need for detergents. (iii) The first use of tagging to identify the binding site of small molecule inhibitors using EM. (iv) The first cryo-EM structure of the V-ATPase complex and the first sub nm V-ATPase reconstruction, providing new insights into the structure and mechanism of this important membrane bound proton pump. I have published over 70 peer-reviewed articles with a h-index of 22.
Research Interests
Papers共 163 篇Author StatisticsCo-AuthorSimilar Experts
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biorxiv(2024)
iScienceno. 1 (2024): 108477-108477
Wesley Tien Chiang,Yao-Kai Chang,Wei-Han Hui, Shu-Wei Chang,Chen-Yi Liao, Yi-Chuan Chang, Chun-Jung Chen,Wei-Chen Wang,Chien-Chen Lai,Chun-Hsiung Wang, Siou-Ying Luo,Ya-Ping Huang,
Nature communicationsno. 1 (2024): 3850-3850
Nature Communicationsno. 1 (2023): 1-12
Communications biologyno. 1 (2023): 358-358
Current opinion in structural biology (2023): 102696-102696
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