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The researchers ruled out foodborne or waterborne agents as well as vaccines and other medicine as potential causes, according to accounts of their investigation. And they noticed that all the patients lived in wooded areas. That point, along with the fact that outbreaks seemed to peak during the summer and early fall, suggested that the cause of the disease might be related to a type of insect.
By 1977, Dr. Malawista and his colleagues had identified the condition that he first labeled “Lyme arthritis.” The name was changed to “Lyme disease” after the ailment was shown to encompass a wide range of symptoms beyond joint pain.
Early indications of Lyme disease include a large, red rash; fevers; chills; and muscle aches. Later-stage symptoms include serious conditions of the heart, joints and nervous system.
Dr. Malawista and his colleagues initially suspected that Lyme disease was caused by a virus, a hypothesis disproven in 1982 when Willy Burgdorfer, a zoologist and microbiologist working in Montana, identified the offending bacterium, which was dubbed Borrelia burgdorferi.
Scientists ultimately identified the deer tick as the carrier of Lyme disease. Dr. Malawista and his colleagues had contributed to that research by comparing the incidence of the illness on the east and west sides of the Connecticut River. They found a higher incidence on the east side, where there was also a greater population of deer and deer ticks, according to an account in the Yale Journal of Biology and Medicine.
In the mid-1980s, Dr. Malawista was credited with helping to demonstrate the effectiveness of antibiotics in treating the disease, particularly when it is caught early.
By 1977, Dr. Malawista and his colleagues had identified the condition that he first labeled “Lyme arthritis.” The name was changed to “Lyme disease” after the ailment was shown to encompass a wide range of symptoms beyond joint pain.
Early indications of Lyme disease include a large, red rash; fevers; chills; and muscle aches. Later-stage symptoms include serious conditions of the heart, joints and nervous system.
Dr. Malawista and his colleagues initially suspected that Lyme disease was caused by a virus, a hypothesis disproven in 1982 when Willy Burgdorfer, a zoologist and microbiologist working in Montana, identified the offending bacterium, which was dubbed Borrelia burgdorferi.
Scientists ultimately identified the deer tick as the carrier of Lyme disease. Dr. Malawista and his colleagues had contributed to that research by comparing the incidence of the illness on the east and west sides of the Connecticut River. They found a higher incidence on the east side, where there was also a greater population of deer and deer ticks, according to an account in the Yale Journal of Biology and Medicine.
In the mid-1980s, Dr. Malawista was credited with helping to demonstrate the effectiveness of antibiotics in treating the disease, particularly when it is caught early.
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Bryan G. Yipp,Björn Petri,Davide Salina,Craig N. Jenne, Brittney N V Scott,Lori Zbytnuik,Keir Pittman,Muhammad Asaduzzaman,Kaiyu Wu,H. Christopher Meijndert,Stephen E. Malawista, Anne de Boisfleury Chevance,
Nature Medicineno. 9 (2012): 1386
Bryan G. Yipp,Björn Petri,Davide Salina,Craig N. Jenne, Brittney N V Scott,Lori Zbytnuik,Keir Pittman,Muhammad Asaduzzaman,Kaiyu Wu,H. Christopher Meijndert,Stephen E. Malawista, Anne de Boisfleury Chevance,
Nature Medicineno. 9 (2012): 1386
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