基本信息
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Bio
Our goal is to understand the molecular mechanisms whereby the genomic RNA of influenza-like viruses is, on the one hand, the template for transcription and replication of the viral genome by its RNA-dependent RNA polymerase and, on the other hand, an Achilles’ heel, whose recognition as non-self can trigger an innate immune response to counter the viral infection. Molecular warfare between the virus and the host-cell occurs at many levels. Influenza polymerase has a unique mechanism of transcription priming called ‘cap-snatching’, which involves pirating short-capped oligomers from nascent cellular Pol II transcripts; this contributes to shutdown of host-cell gene expression. The cell counters RNA viruses with innate immune pattern-recognition receptors, such as the RNA helicase RIG-I, which recognise particular viral RNA structural motifs (e.g. 5′ triphosphate-dsRNA) as non-self, thus activating a signalling pathway leading to interferon production and establishment of the anti-viral state. In response, viruses deploy proteins as counter-counter-measures to dampen the immune response, for instance, by supressing the RIG-I signalling pathway.
Research Interests
Papers共 403 篇Author StatisticsCo-AuthorSimilar Experts
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Maud Dupont,Tim Krischuns,Quentin Giai Gianetto,Sylvain Paisant,Stefano Bonazza,Jean-Baptiste Brault,Thibaut Douche,Benoit Arragain, Alberto Florez-Prada,Joel Perez-Perri,Matthias W. Hentze,Stephen Cusack,
NUCLEIC ACIDS RESEARCHno. 12 (2024): 7188-7210
Amélie BARCZYK,Perrine SIX, Morgane RIVOAL, Claire DEVOS,Xavier DEZITTER, Min-Jeong CORNU-CHOI,Karine HUARD,Erika PELLEGRINI,Stephen CUSACK,Laurent DUBUQUOY,Régis MILLET,Natascha LELEU-CHAVAIN
crossref(2024)
Nature Communicationsno. 1 (2024): 1-20
Nature Communicationsno. 1 (2023): 1-19
PLOS Pathogensno. 1 (2023): e1011073-e1011073
biorxiv(2023)
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Author Statistics
#Papers: 403
#Citation: 27560
H-Index: 89
G-Index: 160
Sociability: 7
Diversity: 0
Activity: 1
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