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Bio
My research focuses on PI3K and its role in the inflammatory process. Since the discovery of the prototypical PI3K in the late 1980’s, the family of PI3Ks and their lipid products (PI(3)P, PI(3,4)P2 and PI(3,4,5)P3 [PIP3]) have been the focus of intense investigation. Since the mid-1990’s I have used pharmacological and molecular approaches to identify the biochemical and physiological importance of PI3K-dependent-signalling pathways in the immune system. PI3Ks regulate important signalling cascade(s) involved in a plethora of cellular functional events such as survival, gene regulation, cell migration, growth and proliferation. My group is currently studying the activation of this signalling cascade during activation of the immune system. Specifically we are interested in the role that this molecule and its downstream biochemical and functional effectors play in key immune cells such as lymphocytes, macrophages, mast cells and eosinophils following activation by antigen, inflammatory mediators (e.g. chemokines and cytokines) and novel phospholipids immune regulators.
Research Interests
Papers共 429 篇Author StatisticsCo-AuthorSimilar Experts
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Zeguo Sun,Zhengzi Yi,Chengguo Wei, Wenlin Wang,Paolo Cravedi,Fasika Tedla,Stephen C. Ward,Evren Azeloglu,Daniel R. Schrider,Yun Li, Sumaria Ali, Tianyuan Ren,
biorxiv(2024)
Samuel Eisenstein, Brian A. Coakley, Karen Briley-Saebo,Ge Ma,Hui-ming Chen,Marcia Meseck,Stephen Ward,Celia Divino,Savio Woo,Shu-Hsia Chen,Ping-Ying Pan
crossref(2023)
Transplantationno. 5 (2023): E154-E155
Lissete Sánchez-Magraner,James Miles, Claire L. Baker,Christopher J. Applebee,Dae-Jin Lee,Somaia Elsheikh, Shaimaa Lashin,Katriona Withers,Andrew G. Watts,Richard Parry,Christine Edmead,Jose Ignacio Lopez,
crossref(2023)
HUMAN PATHOLOGY (2023): 69-77
Noam Harpaz,Samarth Hegde, Lisa Fitzgerald,Stephen Ward,Miriam Merad,Thomas Marron, Zheng Zhu,Qingqing Liu,Celina Ang,Deborah Doroshow,Umut Sarpel,Kathy Wu,
Journal for ImmunoTherapy of Cancerno. Suppl 1 (2023)
Thomas U. Marron,Laura Brennan,Pauline Hamon,Maria Isabel Fiel,Stephen C. Ward, Yuan O. Zhu,Edward Kim,Alice O. Kamphorst,Pradeep Thanigaimani,Thomas S. Uldrick, Natalie Lucas, Kathy Wu,
CANCER RESEARCHno. 7 (2023)
Zhengzi Yi,Caixia Xi,Madhav C. Menon,Paolo Cravedi,Fasika Tedla, A. Juárez Soto,Zeguo Sun,Keyu Liu, Jason Zhang,Chengguo Wei, Man Chen, Wenlin Wang,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
European journal of radiology (2023): 111077-111077
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