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Integrity in axon guidance and axon branching is required for the functional organization of the nervous system. Both axon guidance and axon branching employ the same fundamental cellular machinery: a dynamic cytoskeleton produces the force to initiate axonal plasma membrane protrusion, while vesicle trafficking supplies phospholipids and membrane proteins to the dramatically expanding axonal plasma membrane. Extracellular guidance cues, such as netrin, likely coordinate cytoskeletal dynamics and vesicle trafficking to elicit specific neuronal responses. In my lab we are investigating the role of two neuronally-expressed ubiquitin ligases, TRIM9 and TRIM67, in netrin-dependent axon guidance and branching. We utilize a variety techniques including high resolution live cell microscopy, gene disruption, mouse models, microfluidics and biochemistry to understand the complex coordination of cytoskeletal dynamics and membrane trafficking driving neuronal shape change and growth cone motility in primary neurons and in the developing vertebrate mammalian nervous system.
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Papers共 145 篇Author StatisticsCo-AuthorSimilar Experts
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bioRxiv the preprint server for biology (2024)
bioRxiv : the preprint server for biology (2024)
Ryan D. Mouery, Kimberly Lukasik, Carolyn Hsu,Thomas Bonacci,Derek L. Bolhuis,Xianxi Wang,C. Allie Mills, E. Drew Toomer, Owen G. Canterbury, Kevin C. Robertson,Timothy B. Branigan, Nicholas G. Brown,
Cell reportsno. 8 (2024): 114510-114510
JOURNAL OF CELL SCIENCEno. 2 (2024)
Journal of cell science (2024)
bioRxiv : the preprint server for biologyno. 5 (2024): ar67-ar67
Cancer Researchno. 6_Supplement (2024): 193-193
CB/Current biologyno. 3 (2023): R98-R100
MOLECULAR BIOLOGY OF THE CELLno. 2 (2023): 876-876
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#Papers: 145
#Citation: 4995
H-Index: 29
G-Index: 47
Sociability: 5
Diversity: 2
Activity: 22
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