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Research in the Bielas lab is aimed at understanding the epigenetic and molecular mechanisms of stem cell multipotency, self-renewal and neurogenesis required to build a brain. We develop these project from our human genetic studies aimed at identifying the genetic basis of neurodevelopmental disorders. A major challenge to investigating cell and molecular mechanisms of neurodevelopmental disorders has been the lack of affected tissue. To address this problem we use human brain organoid cultures, differentiated from human pluripotent stem cells (hPSCs) and transgenic mice as model systems. Our goal is to elucidate the pathology of clinically important neurological disorders and novel features of human brain development.
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论文共 66 篇作者统计合作学者相似作者
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Elizabeth A. Werren, Geneva R. LaForce,Anshika Srivastava, Delia R. Perillo, Shaokun Li,Katherine Johnson,Safa Baris, Brandon Berger, Samantha L. Regan, Christian D. Pfennig,Sonja de Munnik,Rolph Pfundt,
Nature Communicationsno. 1 (2024): 1-21
Elizabeth A Werren,Emily R Peirent, Henna Jantti, Alba Guxholli, Kinshuk Raj Srivastava, Naama Orenstein, Vinodh Narayanan, Wojciech Wiszniewski,Mateusz Dawidziuk, Pawel Gawlinski,Muhammad Umair,Amjad Khan,
Cell death & diseaseno. 5 (2024): 379-379
Le Tran Phuc Khoa,Wentao Yang,Mengrou Shan,Li Zhang,Fengbiao Mao,Bo Zhou,Qiang Li, Rebecca Malcore, Clair Harris, Lili Zhao,Rajesh C. Rao,Shigeki Iwase,
Le Tran Phuc Khoa,Wentao Yang,Mengrou Shan, Li Zhang,Fengbiao Mao,Bo Zhou,Qiang Li, Rebecca Malcore, Clair Harris,Lili Zhao,Rajesh C. Rao,Shigeki Iwase,
NATURE COMMUNICATIONSno. 1 (2024)
Purvi Majethia,Namanpreet Kaur, Selinda Mascarenhas,Lakshmi Priya Rao,Shruti Pande,Dhanya Lakshmi Narayanan,Vivekananda Bhat,Shalini S Nayak,Karthik Vijay Nair, Adarsh Pooradan Prasannakumar,Ankur Chaurasia, Bhagesh Hunakunti,
Clinical genetics (2024)
Stephanie Bielas,Charles Ryan,Samantha Regan,Yao-Chang Tsan, Eleanor Mills, Emily Gong, Yi-Ting Lai, Jason Sheingold, Khushboo Patel, Theodore Horowitz,Amanda Moccia, Anshika Srivast
crossref(2024)
biorxiv(2023)
Shruti Pande,Purvi Majethia,Karthik Nair,Lakshmi Priya Rao, Selinda Mascarenhas,Namanpreet Kaur,Michelle C. do Rosario,Kausthubham Neethukrishna,Ankur Chaurasia, Bhagesh Hunakunti, Nalesh Jadhav, Sruthy Xavier,
American journal of medical genetics. Part Ano. 8 (2023): 2175-2180
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