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Integrity in axon guidance and axon branching is required for the functional organization of the nervous system. Both axon guidance and axon branching employ the same fundamental cellular machinery: a dynamic cytoskeleton produces the force to initiate axonal plasma membrane protrusion, while vesicle trafficking supplies phospholipids and membrane proteins to the dramatically expanding axonal plasma membrane. Extracellular guidance cues, such as netrin, likely coordinate cytoskeletal dynamics and vesicle trafficking to elicit specific neuronal responses. In my lab we are investigating the role of two neuronally-expressed ubiquitin ligases, TRIM9 and TRIM67, in netrin-dependent axon guidance and branching. We utilize a variety techniques including high resolution live cell microscopy, gene disruption, mouse models, microfluidics and biochemistry to understand the complex coordination of cytoskeletal dynamics and membrane trafficking driving neuronal shape change and growth cone motility in primary neurons and in the developing vertebrate mammalian nervous system.
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bioRxiv : the preprint server for biology (2024)
Ellen C O'Shaughnessy,Mable Lam, Samantha E Ryken, Theresa Wiesner, Kimberly Lukasik,J Bradley Zuchero,Christophe Leterrier,David Adalsteinsson,Stephanie L Gupton
Journal of cell science (2024)
Laura E. Mccormick,Cristian Suarez, Laura E. Herring,Kevin S. Cannon,David R. Kovar, Nicholas G. Brown,Stephanie L. Gupton
JOURNAL OF CELL SCIENCEno. 2 (2024)
Laura E McCormick,Cristian Suarez,Laura E Herring,Kevin S Cannon,David R Kovar, Nicholas G Brown,Stephanie L Gupton
Journal of cell science (2024)
bioRxiv : the preprint server for biologypp.mbcE23120476-mbcE23120476, (2024)
Cancer Researchno. 6_Supplement (2024): 193-193
Current biology : CBno. 3 (2023): R98-R100
CELL REPORTSno. 8 (2023)
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