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Correa lab is interested in understanding how reproductive hormones affect temperature and energy balance. In women, menopausal transition is associated with hot flashes and increased visceral fat. Our study aims to understand how estrogen acts on the hypothalamus to change temperature homeostasis and metabolic health. These studies can help us better understand weight gain and hot flashes in postmenopausal women. In order to understand the mechanism of estrogen changing homeostasis, we focus on the following broad questions: how does the brain regulate temperature and energy balance? What are the differences in steady-state neural circuits between men and women? How does estrogen regulate the homeostatic circuit? We used genetically engineered mice and new viral tools to define neurons that drive changes in estrogen response and gender specific energy balance. This method enables us to analyze the effects of estrogen on different neuronal populations with spatial, molecular and temporal specificity. Finally, we hope to find ways to develop targeted non hormonal therapies for hot flashes and obesity.
研究兴趣
论文共 32 篇作者统计合作学者相似作者
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Physiologyno. S1 (2024)
Megan G. Massa, Rachel L. Scott, Alexandra L. Cara,Laura R. Cortes, Norma P. Sandoval,Jae W. Park, Sahara Ali,Leandro M. Velez,Bethlehem Tesfaye, Karen Reue,J. Edward van Veen, Marcus Seldin,
iScienceno. 10 (2023): 107918-107918
bioRxiv (2021)
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