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The mission of the Gantz lab is to discover and characterize novel interactions between G protein-coupled receptors and ion channels in the brain. We use patch-clamp electrophysiology in brain slices to record synaptic communication between neurons. We also record ion channel activity directly in dissociated neurons using a multi-barrel perfusion system that allows for better voltage-clamp to assay biophysical properties and high-throughput screening of interacting compounds. Electrophysiological studies are often complemented with histochemistry, microscopy, genetic strategies, and behavioral approaches. Recently, we discovered that alpha1-adrenergic receptors in serotonin neurons augment current carried by orphan delta glutamate receptor 1 (GluD1)-channels to promote action potential firing. Known more broadly as a scaffold protein, very little is known about the ionotropic nature of GluD1. There are no known agonists that gate the channel. Thus, our latest research raises an intriguing question: What is opening GluD1?
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论文共 24 篇作者统计合作学者相似作者
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Serena B. Gumusoglu,Michaela D. Kiel,Aleigha Gugel,Brandon M. Schickling, Kaylee R. Weaver,Marisol C. Lauffer, Hannah R. Sullivan, Kaylie J. Coulter,Brianna M. Blaine,Mushroor Kamal,Yuping Zhang,Eric J. Devor,
Neuropsychopharmacologyno. 5 (2024): 864-875
Neuropsychopharmacologypp.1-10, (2024)
biorxiv(2023)
EMBO Reportsno. 7 (2023)
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