The basic approach of Schurmans team is to genetically modify/mutate genes in mice and to analyze the effects of these mutations on the development and function of the whole organism. From these studies, we are establishing basic principles of physiology and basic mechanisms of disease pathogenesis in animal and man, as well as defining new targets for innovative therapies and diagnosis. In particular, the laboratory focuses on genes implicated in the control of inositol phosphates and phosphoinositides metabolism and signaling.