基本信息
浏览量:6
职业迁徙
个人简介
For more than ~30 years, my work has focused on the analysis of the fundamental mechanisms by which macrophage differentiation facilitates or restricts infectious agents or tumor growth. My laboratory has made seminal contributions to the area of immunology that we now call “innate immunity,” and specifically, the mechanisms by which Toll-like receptor (TLR) signaling is regulated. We have characterized many of the fundamental mechanisms by which TLR agonists, such as Gram negative lipopolysaccharide (LPS), and cytokines and interferons regulate macrophage functions. Moreover, we have used a model of "endotoxin tolerance" to study the regulation of such signaling pathways.
The creative use of genetic, molecular, and biochemical approaches, combined with unique animal models of infection, has led to our most recent, highly translational work, resulting in novel therapeutic approaches for influenza and respiratory syncytial virus (RSV), development of small molecule TLR antagonists based on the structural interactions of innate signaling molecules, and a prototype vaccine for the biothreat agent, Francisella tularensis.
In toto, I have published ~300 peer-reviewed publications plus ~50 invited works, have mentored 35 post-doctoral fellows and 11 graduate students, and am currently director of a T32 entitled “Signaling pathways in innate immunity.” I have had continuous NIH funding for more than 34 years, including a "NIH Merit Award," in addition to other sources of grant support. Collectively, my record shows that I have developed the scientific expertise and leadership skills required to direct multiple concurrent projects, multi-component projects, and a training program.
研究兴趣
论文共 596 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
引用0浏览0引用
0
0
Chestno. 4 (2022): 1074A-1074A
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn