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In higher eukaryotes, genes are interrupted by intervening sequences (introns). After the DNA of a gene is copied into pre-mRNA, these intronic sequences have to be removed and the remaining sequences (exons) are joined. This process is known as pre-mRNA splicing. Often, a cell can alternatively include or exclude a sequence from the mature mRNA, a process that is known as alternative splicing. Alternative splicing is an important mechanism to create protein diversity. It allows to create more than one protein from a given pre-mRNA, or to switch off the protein by including a stop codon in its mRNA. Alternative splicing pathways are not static, but subject to changes e.g. in development, or in response to outside stimuli. Numerous examples of alternative splicing have been observed in the brain, where this mechanism might contribute to neuronal plasticity.
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论文共 124 篇作者统计合作学者相似作者
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Giorgi Margvelani,Justin R. Welden, Andrea Arizaca Maquera,Jennifer E. Van Eyk,Christopher Murray,Sandra C. Miranda Sardon,Stefan Stamm
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASEno. 4 (2024): 167036-167036
Karol Andrea Arizaca Maquera,Justin Ralph Welden,Giorgi Margvelani,Sandra C Miranda Sardón, Samantha Hart, Noémie Robil,Alvaro Gonzalo Hernandez, Pierre de la Grange,Peter T Nelson,Stefan Stamm
Frontiers in molecular neuroscience (2023): 1141079-1141079
Journal of Biological Chemistryno. 3 (2023): 104231-S667
Justin Ralph Welden,Giorgi Margvelani,Karol Andrea Arizaca Maquera, Bhavani Gudlavalleti,Sandra C Miranda Sardón,Alexandre Rosa Campos,Noémie Robil, Daniel C Lee,Alvaro G Hernandez,Wang-Xia Wang,Jing Di,Pierre de la Grange,
Journal of Visualized Experiments (2020)
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