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Bio
Dr. McArdle is a Senior Research Scientist in Tumour Immunology who leads the development of T-cell vaccines against cancers. In particular, Dr. McArdle has identified a mutated Prostatic Acid Phosphatase, PAP, derived sequence, which, when injected with CAF09, a strong adjuvant (kind gift from Dr. Dennis Christensen) has now been granted patent in Europe and in the US. Preclinical works are ongoing to gather the necessary data for a phase-0/I clinical trial for the treatment of hormone resistant prostate cancer. Dr. McArdle is also working on a HAGE- and mutated NY-ESO1-derived peptide sequences for the treatment of Triple Negative Breast Cancer (TNBC).
Dr. McArdle collaborates with many European laboratories which offers strong adjuvants such as CAF09 (Dr. Dennis Christensen, Serum Institute, Denmark), Immune-complexes (Dr. Sara Mangsbo (Upsala University, Sweden), L-Dopa, a precursor of melanin (Dr. Antoine Carpentier, Université Paris Descartes, Paris, France) as well as UK collaborator such as Prof. Lindy Durrant (Immunobody®, Nottingham University).
Dr. McArdle has also a particular interest in the effect of exercise, mental health and gut microbiota on the immune system of cancer patients and a study in ongoing in prostate cancer patients to assess the level of inflammation related molecules, the psychological status and the gut permeability of prostate benign vs cancer patients. She is keen to emphasise the importance of one’s life style on one’s health. She has previously organised three “Health and Well Being” days dedicated to promote self-help.
Research Interests
Papers共 112 篇Author StatisticsCo-AuthorSimilar Experts
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Frontiers in immunology (2024): 1407930-1407930
Joshua R. D. Pearson, Carles Puig-Saenz, Jubini E. Thomas, Lydia D. Hardowar,Murrium Ahmad, Louise C. Wainwright, Adam M. McVicar,Victoria A. Brentville, Chris J. Tinsley,A. Graham Pockley,Lindy G. Durrant,Stephanie E. B. McArdle
Joshua R D Pearson, Carles Puig-Saenz, Jubini E Thomas, Lydia D Hardowar,Murrium Ahmad, Louise C Wainwright, Adam M McVicar,Victoria A Brentville, Chris J Tinsley,A Graham Pockley, Lindy G Durrant,Stephanie E B McArdle
Adeola Grace Atobatele,Elisa Tonoli,Jayakumar Vadakekolathu,Maria Pia Savoca, Melissa Barr, Yukti Kataria,Marta Rossanese,Izhar Burhan,Stephanie McArdle,Daniela Caccamo,Elisabetta A. M. Verderio
Journal of cellular and molecular medicineno. 2 (2023): e18061-e18061
FEBS Open Biono. 7 (2023): 1266-1277
Pauline Le Vu,Jayakumar Vadakekolathu,Sarra Idri,Holly Nicholls, Manon Cavaignac,Stephen Reeder,Masood A Khan,Dennis Christensen,Alan Graham Pockley,Stéphanie E McArdle
Adeola Atobatele,Elisa Tonoli,Jayakumar Vadakekolathu,Maria Pia Savoca, Melissa Barr, Yukti Kataria,Marta Rossanese,Izhar Burhan,Stephanie McArdle,Daniela Caccamo,Elisabetta Verderio
Research Square (Research Square) (2022)
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