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In subsequent work as a faculty member at OHSU, Dr. Impey used functional genomic approaches to identify microRNAs regulated by CREB, neuronal activity, and epilepsy-associated seizures. These approaches led the Impey lab to identify the microRNA 132-212 gene as a rapid response gene that promotes neuronal maturation and synaptogenesis. Hundreds of studies have subsequently implicated this microRNA gene in memory consolidation, brain plasticity, and other adaptive phenotypes.
Subsequent work by the Impey lab has focused on characterization of additional non-coding plasticity-regulated genes and the use of epigenetic profiling to identify pathways linked to brain plasticity mechanisms and neurological disease.
Research Interests:
Functional genomic studies of non-coding RNAs associated with plasticity and epilepsy
Dynamic histone and DNA methylation in plasticity and neurodegenerative disorders
CREB-regulated microRNAs and their target gene networks
Role of OTX2-regulated transcription in Parvalbumin neuron plasticity
Subsequent work by the Impey lab has focused on characterization of additional non-coding plasticity-regulated genes and the use of epigenetic profiling to identify pathways linked to brain plasticity mechanisms and neurological disease.
Research Interests:
Functional genomic studies of non-coding RNAs associated with plasticity and epilepsy
Dynamic histone and DNA methylation in plasticity and neurodegenerative disorders
CREB-regulated microRNAs and their target gene networks
Role of OTX2-regulated transcription in Parvalbumin neuron plasticity
Research Interests
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Scientific Reportsno. 1 (2017)
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