Long dated experience in the morphological characterisation of several cell types, using transmission electron microscopy particulary with immunocytochemistry analyses. Experience in scanning electron microscopy has been acquired during the professional career. In the last years, I have been particularly involved in characterising the mast cell, as a prototype of a cell, which plays a pivotal role in several immunopathologies. At the present, I am fully involved in the investigation on annexin 1 localisation and mobilisation in mast cells and leukocytes by immunocytochemical analysis, with particular reference to the process of inflammation. Over the years this has proved to be a fertile study and my collegues and I have investigated the functional and ultrastructural analysis of annexin 1 and its receptor in extravasating neutrophils during acute inflammation.