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Bio
Sofia Duque Santos is a Senior Post-Doctoral Researcher at the Nanobiomaterials for Targeted Therapies group (nBTT), at Instituto de Investigação e Inovação em Saúde (i3S), University of Porto.
SD Santos graduated in Biochemistry in 2000, at University of Porto, Portugal.
As initial research studies, she went to Stockholm University, Sweden, under the ERASMUS mobility program.
After, SD Santos began her Ph.D. in Neuroscience, under professor MJ Saraiva supervision, at Amyloid Unit, IBMC, Porto, Portugal. The thesis focused on a neurodegenerative disease of the peripheral nervous system - Familial Amyloidotic Polyneuropathy (FAP). SD Santos made numerous contributions for the understanding of factors modulating FAP, including the stress response, the ubiquitin proteasome system, the unfolded protein response and the heat shock proteins. SD Santos also established a mostly relevant mice model showing amyloid deposition on PNS for the 1st time. During her Ph.D., she spent a period in Columbia University (USA) as an invited researcher, to further address questions related to transthyretin (TTR) amyloidogenesis.
As a Postdoctoral researcher, in 2005 at Molecular Neurobiology Unit, with Professor MJ Saraiva, SD Santos began a new line of research focused on mechanisms of injury in the CNS. SD Santos went to the Medical Biotechnology Center in Odense, Denmark, to acquire knowledge in an ischemic stroke animal model. With this model, she studied both TTR and the heat shock transcription factor 1 (HSF1) in the ischemic pathological cascade. She discovered the relevant role for these proteins, in the formation of the cerebral infarct. To distinguish the tissue source of the TTR responsible for stroke protection, a siRNA approach was applied in vivo. This demonstrated that downregulation of the hepatic TTR production did not affect the choroid plexus TTR production and consequent neuroprotection.
Later, as an assistant researcher in the group of Dr. J Relvas at IBMC, Porto, she addressed the Rho GTPases signaling (Rac1 and RhoA) in brain ischemia, by using inducible and conditional gene ablation technology in mice. This study revealed that neuronal cell specific Rac1 downregulation led to a major impact in stroke neurological injury.
SD Santos moved to INEB/i3S in 2016 to work with Dr AP Pêgo in the field of nanobiomaterials. Her aim is to deliver nucleic acids as neurotherapeutics in mice pre-clinical studies of stroke, using functionalized carriers. She is currently working with a derivative of chitosan and with a biodegradable dendrimer to transport oligonucleotides with impact in oxidative stress defences and with BDNF mRNA for neuroprotection and neurorepair in Stroke.
SD Santos’ scientific career has followed a path in Neuro- and Molecular Biology that has created knowledge for research in biomedicine towards nervous system injuries, together with nanomedicine and nucleic acid-based therapy in Stroke.
Research Interests
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Biomaterials scienceno. 14 (2023): 5012-5024
D. J. Demetrick,M. Perizzolo,A. Stuart,S. Santos,C. Charlton, C. Watt, N. Lozano, S. Shell, S. Hummel,A. Sartori, M. Mosko, A. Nakorchevsky,
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