Robert W. Sobol
教授
Department of Pathology and Laboratory Medicine
Warren Alpert Medical School, Brown University;Legorreta Cancer Center, Brown University;Brown Institute for Translational Science;Lifespan Cancer Institute;Department of Pharmacology, College of Medicine, University of South Alabama;Greater Caribbean Center for Ciguatera Research, Florida Gulf Coast University;Greater Caribbean Center for Ciguatera Research, University of South Alabama Mitchell Cancer Institute;Department of Pharmacology & Chemical Biology, School of Medicine, University of Pittsburgh
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基本信息
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个人简介
At Brown, my lab’s research will focus on the role of the DNA base excision repair pathway in the regulation of PARP activation and the response to replication stress, and the identification of novel targets to overcome PARP-inhibitor resistance. We are also working on the development of novel biological tools and assays to evaluate PARP-activation, genotoxic stress, and gene-environment interactions and the utilization of these novel tools for the analysis of tumor response, the response to industrial pollutants, and the discovery of molecules that inhibit cellular repair. Further, my lab has a translational focus on how these PARP-dependent DNA damage response pathways impact tumor cell survival, genotoxicity, cellular aging, and response to chemo- and immune checkpoint-based therapies.
研究兴趣
论文共 290 篇作者统计合作学者相似作者
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Journal of Molecular Biologyno. 4 (2024): 168410-168410
Md Ibrahim, Md Maruf Khan, Rasha Q. Al-Rahaleh,Jennifer Clark,Faisal Hayat,Qingming Fang, Christopher A. Koczor,Marie E. Migaud,Robert W. Sobol
Cancer Researchno. 6_Supplement (2024): 7131-7131
Burcu Inanc,Qingming Fang,Joel F Andrews,Xuemei Zeng,Jennifer Clark,Jianfeng Li,Nupur B Dey, Md Ibrahim,Peter Sykora,Zhongxun Yu,Andrea Braganza,Marcel Verheij,
bioRxiv : the preprint server for biology (2024)
Pinakin Pandya,Frank P. Vendetti, Joseph A. Ghoubaira, Sudipta Pathak,Joshua J. Deppas,Reyna E. Jones, Yunqi Zhang, Daniel Ivanov,Raquel Buj,Katherine M. Aird,Jan H. Beumer,Robert W. Sobol,
CANCER RESEARCHno. 1 (2024)
JOURNAL OF MOLECULAR BIOLOGYno. 4 (2024)
Cancer Researchno. 6_Supplement (2024): 7129-7129
DNA Repair (2024): 103677
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