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个人简介
I am getting interested for 20 years in molecular and cellular mechanisms regulating white adipose tissue (WAT) physiopathology and obesity-associated metabolic diseases (type II diabetes, cardiovascular diseases or non-alcoholic steatohepatitis/NASH) whose occurrence dramatically increased over the past few years.
WAT constitutes the main energy supply in the body, being mobilized according to body needs, which implies a permanent communication with other cells composing WAT as well as with other organs. In addition, adipocyte, the functional cell unit of WAT dedicated to lipid storage, has to face with drastic changes in cell size volume depending on hormonal and nutritional status.
Based on a solid background and knowledge in lipid trafficking and adipocyte cellular biology, my research focuses on adipocyte membrane remodeling processes occurring during obesity. We aim to test that WAT derived-extracellular vesicles (EVs) act as a mode of intercellular communication and participate to the onset of metabolic complications related to obesity. Original and innovative approaches are employed to better characterize EVs in term of proteins, lipid and genetic material content. The impact of EVs on the metabolism of adipocytes, macrophages and hepatocytes constitute the heart of my studies.
EVs recently appeared as powerful tools which can be used as diseases biomarkers and therapeutic vectors in clinics. My research theme therefore takes part of this emerging field in the perspective to use EVs to prevent from cardiometabolic complications.
研究兴趣
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Alexia Blandin,Isabelle Dugail,Grégory Hilairet,Maharajah Ponnaiah,Valentine Ghesquière, Josy Froger,Simon Ducheix,Lionel Fizanne, Jérôme Boursier,Bertrand Cariou,Marie Lhomme,Soazig Le Lay
Cell reportsno. 3 (2023): 112169-112169
Annales d'Endocrinologieno. 5 (2022): 271-272
Cell reportsno. 2 (2022): 110213-110213
Alexia Blandin,Jérémy Amosse,Grégory Hilairet, Maëva Durcin,Xavier Prieur,Luisa Vergori,Cédric Dray,Jean-Philippe Pradère, Joëlle Dupont,Pierre-Henri Ducluzeau,Séverine Dubois, Jerome Boursier,
Social Science Research Network (2022)
M S-medecine Sciencesno. 12 (2021): 1125-1132
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