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Career Trajectory
Bio
I lead a research team in HKU focusing mainly on Parkinsons disease (PD), its etiology, pathogenesis and exploring therapeutic methods to modify these processes. Our earlier research described how a ubiquitous xenobiotic enzyme, catechol-O-methyltransferase (COMT) provided the link between the effects of estrogen and PD. This project delivered tangible materials including human COMT antibodies and a patented COMT ELISA assay containing a unique synthetic 18 amino acid polypeptide protein tag. This enzyme assay can quantify the estrogenic effects of environmental pollutants, such as PCBs and plasticizers linked to cancer and neurodegeneration. It is being used by our collaborators in environmental sciences to study the extent and effects of marine pollution in Hong Kong on human health.
Research Interests
Papers共 219 篇Author StatisticsCo-AuthorSimilar Experts
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Archives of physical medicine and rehabilitation (2024)
Archives of Physical Medicine and Rehabilitation (2024)
Kay-Cheong Teo, Sze-Man Fong,William C Y Leung,Ian Y H Leung,Yuen-Kwun Wong, Olivia M Y Choi,Ka-Keung Yam, Rachel C N Lo,Raymond T F Cheung,Shu-Leong Ho,Anderson C O Tsang,Gilberto K K Leung,
Strokeno. 6 (2023): 1548-1557
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