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职业迁徙
个人简介
Research
Development and Disease
My group is interested in understanding the genetic control of mammalian development and how abnormalities in this process lead to diseases. We have been using transgenic and ‘knockout’ mice to elucidate gene function. Our current focus is on the TSPYL family proteins. TSPYL proteins belong to the nucleosome assembly protein family with a putative role in the epigenetic control of gene expression. We have generated Tspyl2 knockout mice and demonstrated a role of TSPYL2 in cell cycle control. In addition, TSPYL2 controls gene expression in neurons.
Our group has a long standing interest in elucidating gene function. We have reported the functions of epidermal growth factor (EGF) and RET receptor tyrosine kinase. We have revealed a role of EGF in the hair growth cycle, spermatogenesis, bone growth and recently, dopamine metabolism. Abnormal EGF or RET signalling results in cancer. We are now testing whether TSPYL family proteins also have a role during embryonic development and in cancer.
研究兴趣
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Huiqi Tan, Mia Xinfang Miao, Rylee Xu Luo,Joan So,Lei Peng,Xiaoxuan Zhu,Eva Hin Wa Leung,Lina Zhu,Kui Ming Chan,Martin Cheung,Siu Yuen Chan
ADVANCED SCIENCE (2024)
F&S Scienceno. 2 (2020): 115-123
Chi Ho Chong,Qi Li,Priscilla Hoi Shan Mak, Cypress Chun Pong Ng,Eva Hin Wa Leung, Vicky Huiqi Tan, Anthony Kin Wang Chan,Grainne McAlonan,Siu Yuen Chan
Biochemical and biophysical research communicationsno. 1 (2019): 22-28
Hang Liu,Lei Peng,Joan So, Ka Hing Tsang, Chi Ho Chong, Priscilla Hoi Shan Mak,Kui Ming Chan,Siu Yuen Chan
semanticscholar(2018)
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