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Mechanism of trichosanthin action: Trichosanthin is a type I ribosome inactivating protein with antiviral activity. It inhibits replication of human immunodeficiency virus (HIV) as well as Herpes Simplex Virus (HSV). The mechanism is not known. Results found in this laboratory support the hypothesis that trichosanthin selectively induce apoptosis in viral infected cells while sparing uninfected cells. Infected cells die prematurely and therefore limit viral replication. The mechanism appears to involve the MAPK signal pathway.
Genetic adaptation of high altitude: Studying the genetic difference between Tibetan and Han and looking for genes contributing to better survival in high altitude.
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Papers共 47 篇Author StatisticsCo-AuthorSimilar Experts
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Cynthia M Beall,Gianpiero L Cavalleri,Libin Deng,Robert C Elston,Yang Gao,J. Knight,Chaohua Li, Jiang Chuan Li, Y. Liang,Mark McCormack,Hugh E Montgomery,Hao Pan,
LEUKEMIA RESEARCHno. 9 (2010): 1195-1202
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