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The Buczacki lab is interested primarily in the role sub-clonal interactions play on colorectal cancer cell identity and behaviour. We believe that the behaviour of normal intestinal cells is often analogous to that seen in oncogenically transformed cells and thus, we also study the behaviour of progenitor and differentiated cells from normal intestinal tissues to provide insights into cancer cell behaviour. We are particularly interested in understanding the mechanisms and links behind cancer plasticity and identity switching. The lab is also interested in understanding the fundamental biology of small intestinal neuro-endocrine tumours through organoid biology and mouse modelling.
研究兴趣
论文共 49 篇作者统计合作学者相似作者
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JOURNAL OF CLINICAL INVESTIGATIONno. 23 (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
STAR Protocolsno. 1 (2023): 101978-101978
Dimitrios A Koutoukidis,Susan A Jebb,Claire Foster, Pete Wheatstone,Alison Horne, T Martyn Hill, Amy Taylor,Alba Realpe,Felix Achana,Simon J A Buczacki
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Irelandno. 9 (2023): 1910-1920
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Dimitrios A. Koutoukidis,Susan A. Jebb,Claire Foster, Pete Wheatstone,Alison Horne, Trevor Hill, Adam Michael Taylor,Alba Realpe,Felix Achana,Simon Buczacki
Colorectal Diseaseno. 9 (2023): 1910-1920
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Eric Jou,Noe Rodriguez-Rodriguez, Ana-Carolina F. Ferreira,Helen E. Jolin,Paula A. Clark, Kovilen Sawmynaden, Michelle Ko,Jane E. Murphy,Jonathan Mannion, Christopher Ward,David J. Matthews,Simon J. A. Buczacki,
Science Immunologyno. 72 (2022)
COLORECTAL DISEASEno. 2 (2022): 153-154
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