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个人简介
Sílvia A Sousa received her PhD degree in Biotechnology in 2007 from the former Technical University of Lisbon (now University of Lisbon), Portugal. In her PhD research, Sílvia studied the role of the exopolysaccharide Cepacian produced by Burkholderia cepacia complex (Bcc) bacteria on the Bcc infections of Cystic Fibrosis (CF) patients. In the PhD, Sílvia also identified new virulence factors of Bcc using a multidisciplinary approach that involved the creation of Bcc mutant collections using random plasposon insertion mutagenesis, screening of the libraries for reduced virulence in the nematode Caenorhabditis elegans, genome sequences data mining, combined with molecular biology, biochemistry and microbiological techniques. As part of the PhD program, from April 2003 to March 2004, Sílvia was a PhD trainee in the group of Prof. Gerd Döring, Institute of Medical Microbiology and Hygiene, University of Tübingen, Germany. Prof. Gerd Döring was an internationally recognized expert in CF research field. In this period, she worked in the development of a mouse model of Bcc infection using X-linked chronic granulomatous disease (X-CGD) mice and in the development of an immunological method for the detection of Bcc bacteria based on the Bcc polysaccharides. Sílvia A. Sousa is currently a researcher at the Biological Sciences Research Group (BSRG), Institute for Bioengineering and Biosciences (iBB). Her current research activities are focused on the microbiology of lung infections in cystic fibrosis patients. In particular, the identification and characterization of virulence factors of bacteria of Bcc, with the objective to identify new targets for the development of new antimicrobials. Identification and exploitation of the immunogenic properties of proteins of the Bcc to design new diagnostic and therapeutic strategies to fight the infections caused by these pathogens.
研究兴趣
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VACCINESno. 2 (2024): 207
ENERGIESno. 10 (2023): 4238-4238
Sônia do Socorro do C. Oliveira, Ramon Diego C. Araújo,Gabriel A. da Silva,Jorge H. Leitão,Silvia Andreia Bento da Silva Sousa,Luis P. Fonseca,José Carlos T. Carvalho,Patrick Cantuária, Lorane I. da S. Hage-Melim,Irlon M. Ferreira
Vera L R Esgueira,Clara P A Lopes, Ana Catarina A Dos Santos,Fátima Pinto,Silvia A Sousa,Dragana P C de Barros,Jorge H Leitão,Luis P Fonseca
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