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The main function of the immune system is to protect the host against pathogens, such as bacteria or viruses. However, unlike the systemic immune system, the gut immune system does not eliminate microorganisms but instead nourishes rich bacterial communities and establishes advanced symbiotic relationships. We aim to understand the feed-forward and feedback mechanisms between microbiota and the immune system at the mucosal barrier. We intend to elucidate the contribution of each component of the immune system to the trademark characteristics of microbiota namely diversity, balance and metabolic functions. This knowledge seems particularly important for translational medicine, especially when considering strategies to correct the defects and to reestablish symbiosis in intestinal pathologies like infections, inflammatory diseases and malabsorbtion associated with various immuno-deficiencies -primary or secondary, single or combined.
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CANCER SCIENCE (2023): 89-89
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Muna Al-Habsi,Kenji Chamoto, Ken Matsumoto,Norimichi Nomura,Baihao Zhang,Yuki Sugiura,Kazuhiro Sonomura, Aprilia Maharani,Yuka Nakajima,Yibo Wu,Yayoi Nomura,Rosemary Menzies,
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