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Research Synopsis
There are three primary thrusts which drive projects in the Hill lab:
I. Reaction Methodology
The development of new reactions is critical for advances in many fields such as pharmaceutical, biological, and material sciences because doing so permits access to unique chemical space. Structurally complex sp3-rich polycyclic products represent under explored chemical space, because reactions that allow direct access to these compounds are lacking. Cycloaddition reactions are powerful in that they allow a rapid increase in structural complexity (rings, stereocenters, incorporation of heteroatoms etc.) oftentimes with starting materials that are synthetically tractable. In the Hill lab, we are interested in developing unique enantioselective cycloaddition reactions where stereocontrol is imparted by the catalyst.
II. Natural Products
Isolated from plants, bacteria, marine sponges and other natural sources, complex secondary metabolites (natural products) oftentimes have important biological function (e.g., active in the central nervous system, anti-HIV, anticancer). As such, this chemical matter provides a unique starting point for the development of new pharmaceuticals. Additionally, these compounds are often used as tools for understanding biology, and their complex architectures are well-suited for investigating molecular reactivity in complex chemical environments. A major thrust in the Hill lab is focused on using natural products as tools for understanding complex biology.
III. Total Synthesis
The sequence of reactions by which a complex natural product is obtained is of paramount importance. Unique synthetic strategies can result in the innovative reaction methodologies, uncover new reactivity of small molecules, and begin to address shortages natural compounds used as leads for drug development. Total synthesis also provides a means to confirm the structure of natural products, which can be critical for understanding how they function. The Hill lab is interested using CH functionalization and cycloaddition reactions as key tactics to access complex natural with function.
There are three primary thrusts which drive projects in the Hill lab:
I. Reaction Methodology
The development of new reactions is critical for advances in many fields such as pharmaceutical, biological, and material sciences because doing so permits access to unique chemical space. Structurally complex sp3-rich polycyclic products represent under explored chemical space, because reactions that allow direct access to these compounds are lacking. Cycloaddition reactions are powerful in that they allow a rapid increase in structural complexity (rings, stereocenters, incorporation of heteroatoms etc.) oftentimes with starting materials that are synthetically tractable. In the Hill lab, we are interested in developing unique enantioselective cycloaddition reactions where stereocontrol is imparted by the catalyst.
II. Natural Products
Isolated from plants, bacteria, marine sponges and other natural sources, complex secondary metabolites (natural products) oftentimes have important biological function (e.g., active in the central nervous system, anti-HIV, anticancer). As such, this chemical matter provides a unique starting point for the development of new pharmaceuticals. Additionally, these compounds are often used as tools for understanding biology, and their complex architectures are well-suited for investigating molecular reactivity in complex chemical environments. A major thrust in the Hill lab is focused on using natural products as tools for understanding complex biology.
III. Total Synthesis
The sequence of reactions by which a complex natural product is obtained is of paramount importance. Unique synthetic strategies can result in the innovative reaction methodologies, uncover new reactivity of small molecules, and begin to address shortages natural compounds used as leads for drug development. Total synthesis also provides a means to confirm the structure of natural products, which can be critical for understanding how they function. The Hill lab is interested using CH functionalization and cycloaddition reactions as key tactics to access complex natural with function.
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crossref(2024)
JOURNAL OF THE AMERICAN CHEMICAL SOCIETYno. 31 (2023): 17389-17397
Isaiah K. Eckart-Frank,Sidney M. Wilkerson-Hill
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)
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crossref(2022)
ACS CENTRAL SCIENCEno. 11 (2020): 1845-1850
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