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Our research is directed at furthering the understanding of protein kinase regulation with a particular focus towards the underlying structural mechanism that imparts specificity to signalling function. We seek to uncover the structural basis for novel catalytic switching, substrate recognition and down-stream phosphoregulatory mechanisms. In addition, we are interested in uncovering the structure and function of new proteins and activities that impact protein kinase function. These efforts have recently led our lab into the area of ubiquitin directed proteolysis. Our long-term goal is to make use of what we learn about protein kinases and phosphoregulatory systems to develop drugs to treat human disease.
Research Interests
Papers共 198 篇Author StatisticsCo-AuthorSimilar Experts
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Tanner M. Tessier, Arvid Chowdhury, Zane Stekel,Julia Fux,Maria Augusta Sartori,Joan Teyra,Nick Jarvik,Jacky Chung,Igor Kurinov,Frank Sicheri,Sachdev S. Sidhu,Alex U. Singer,
Pierre Maisonneuve,Malha Sahmi, Fanny Bergeron-Labrecque, Xianjie Iris Ma, Juliette Queguiner, Geneviève Arseneault,Martin Lefrançois,Igor Kurinov,Rémi Fronzes,Frank Sicheri,Marc Therrien
Nature Structural & Molecular Biologypp.1-11, (2024)
Jay Z. Yin,Alexander F.A. Keszei,Scott Houliston,Frantisek Filandr,Jonah Beenstock,Salima Daou,Julia Kitaygorodsky,David C. Schriemer, Mohammad T. Mazhab-Jafari,Anne-Claude Gingras,Frank Sicheri
Structureno. 6 (2024): 795-811.e6
Protein science : a publication of the Protein Societyno. 1 (2024)
Heather Ann Bruce,Alex U. Singer, E.V. Filippova,Levi L. Blazer,Jarrett Adams,Leonie Enderle,Moshe Ben‐David,Elizabeth Radley,Daniel Y.L. Mao,Victor P.T. Pau,Stephen Orlicky,Frank Sicheri,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Methods in enzymology (2022): 729-773
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