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Bio
His laboratory research was focused on mechanisms of tissue remodeling and repair and clinical studies particularly related to chronic obstructive pulmonary disease and smoking cessation. He has received numerous awards including the Career Research Award of the Department of Internal Medicine, the Scientist Laureate Award of UNMC, and the Outstanding Research and Creativity Award of the University of Nebraska. He has served on the American Board of Internal Medicine, Pulmonary Committee, Board of Directors for the American Lung Association, the American Thoracic Society, the Alpha-1 Foundation and the COPD Foundation, on the initial committee that prepared the GOLD Guidelines and was an author of the COPD Foundation Guide for the Diagnosis and Management of COPD.
From August 2015 through November 2019, he worked at AstraZeneca, Cambridge, UK. Starting as Chief Clinician Scientist in the Clinical Discovery Unit of Early Clinical Development (ECD), he became head of that unit in 2016, was appointed head of IMED Early Clinical Development in November 2017, and was promoted to Senior Vice President in 2018. The ECD had responsibility for clinical trials from the first time in man through Phase 2 including study design, biostatistics, clinical pharmacology and disease modeling, and operations across therapeutic areas. During his time at AstraZeneca, Dr. Stephen led initiatives in patient segmentation, novel clinical trial design and outcomes and human target validation. During his tenure, the ECD initiated novel operations models, clinical designs, target validation and decision-making approaches, which enabled AstraZeneca to establish industry-leading timelines and success rates.
Research Interests
Papers共 834 篇Author StatisticsCo-AuthorSimilar Experts
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Annals of the American Thoracic Societyno. 7 (2024): 1022-1033
ANNALS OF THE AMERICAN THORACIC SOCIETYno. 5 (2024): 727-739
Chronic obstructive pulmonary diseases (Miami, Fla.)no. 3 (2023): 270-285
American journal of respiratory and critical care medicineno. 4 (2023): 395-405
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