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In medical science, biomaterials are used extensively to augment or restore function, and replace tissue. Antimicrobial coatings of device surfaces are required to prevent bacterial colonisation and DAIs. To address this, one of the strategies is the use of cationic antimicrobial peptides (AMPs) as coatings for biomaterials. However, AMPs are susceptible to proteases found in blood or other body fluids. Therefore, development of mimetics of AMPs resistant to proteases as novel anti-infective agents with increased bioavailability is a promising tool in the scientific arena.
Peptoids are non-natural mimics of polypeptides containing poly-N-substituted glycine residues. My research focuses on immobilisation of peptoids on surfaces, and characterizing their mode of action in preventing microbial colonisation on biomaterials. This research will also explore synergy between these peptoids and available antibiotics to combat extensively drug resistant bacteria.
Peptoids are non-natural mimics of polypeptides containing poly-N-substituted glycine residues. My research focuses on immobilisation of peptoids on surfaces, and characterizing their mode of action in preventing microbial colonisation on biomaterials. This research will also explore synergy between these peptoids and available antibiotics to combat extensively drug resistant bacteria.
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Poonam Yadav, Sreska Shrestha, Deepak Basyal,Ananda Tiwari,Ranjit Sah, Anil Shah, Bishal Yadav, Mark Willcox,Shyam Kumar Mishra
crossref(2024)
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The Lancet. Microbeno. 7 (2023): e482-e483
Abhinav Bhattarai,Sangam Shah, Garima Dhakal,Sunraj Tharu, Mandira Khadka,Prakash Sharma, Arun Kharel, Basanta Paudel,Sangharsha Thapa, Prativa Subedi,Shyam Mishra
Authorea (Authorea) (2022)
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