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个人简介
The major research interest in the Chen Laboratory is to manipulate stem cell fate using chemical and biological approaches and to generate functional tissues and organs that can be used for translational research. Our current main focus is on human pluripotent stem cells (PSCs), including human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs). We combine our knowledge of stem cell biology, developmental biology, chemical biology, medicine chemistry and tissue engineering to derive functional cells, tissues and organs from human pluripotent stem cells. Our long-term goal is to apply patient specific PSC-derived tissues or organs for replacement therapy and build up “disease in a dish” platforms for drug discovery.
Dr. Chen is a faculty member in the Tri-Institutional PhD Program in Chemical Biology.
Dr. Chen is a faculty member in the Tri-Institutional PhD Program in Chemical Biology.
研究兴趣
论文共 139 篇作者统计合作学者相似作者
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 1 (2024)
Nature biotechnologypp.1-11, (2024)
International Journal of Molecular Sciencesno. 1 (2023): 154
biorxiv(2023)
Homa Majd,Sadaf Amin,Zaniar Ghazizadeh, Andrius Cesiulis, Edgardo Arroyo,Karen Lankford,Alireza Majd,Sina Farahvashi, Angeline K. Chemel,Mesomachukwu Okoye,Megan D. Scantlen,Jason Tchieu,
Angie Chi Nok Chong,J. Jeya Vandana, Ginnie Jeng,Ge Li, Zihe Meng,Xiaohua Duan,Tuo Zhang,Yunping Qiu,Raimon Duran-Struuck,Kimberly Coker,Wei Wang,Yanjing Li,
NATURE CHEMICAL BIOLOGYpp.1-11, (2023)
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Lei Tan,Xiaohua Duan, Pratyusha Mutyala,Ting Zhou,Sadaf Amin,Tuo Zhang,Brian Herbst,Gokce Askan,Tomer Itkin,Zhaoying Xiang, Fabrizio Michelassi, Michael D. Lieberman,
JOURNAL OF MOLECULAR CELL BIOLOGYno. 6 (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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