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个人简介
Dr. Muallem’s lab studies epithelial transport, specifically in exocrine physiology, and the regulation of enzymes, fluid, and electrolyte secretion by epithelial cells. One focus is calcium (Ca2+) signaling in glandular cells that secrete digestive enzymes and antibacterial peptides that are essential for control of the oral cavity and gut microbiome. The lab studies the gating mechanism governing plasma membrane Ca2+ channels and its role in inflammatory autoimmune diseases such as pancreatitis and Sjögren's syndrome. His group investigates bicarbonate (HCO3-) transporters in ductal HCO3- secretion, which is vital for the function and health of all secretory glands. Defective regulation of HCO3- secretion occurs in many epithelial diseases including cystic fibrosis, Sjögren's syndrome and pancreatitis. Dr. Muallem’s lab combines electrophysiological and imaging techniques with molecular and biochemical approaches to study the organization of Ca2+ signaling at membrane contact sites and the molecular mechanism of ductal fluid and HCO3- secretion.
研究兴趣
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The Journal of clinical investigationno. 7 (2024)
CELL CALCIUM (2023): 102696-102696
Woo Young Chung,Malini Ahuja,Beth A McNally, Spencer R Leibow,Henry K E Ohman, Ava Movahed Abtahi,Shmuel Muallem
Proceedings of the National Academy of Sciences of the United States of Americano. 43 (2022)
Proceedings of the National Academy of Sciences of the United States of Americano. 43 (2022): e2200085119-e2200085119
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