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Shiv Grewal is a Distinguished Investigator at the National Cancer Institute (NCI) recognized for groundbreaking research in the field of epigenetics. His work provided fundamental insight into heterochromatin formation, a compact form of chromatin that inhibits inappropriate gene expression and ensures genome stability. He obtained his Ph.D. from the University of Cambridge in 1992, where he held the prestigious Cambridge-Nehru scholarship. As a post-doctoral fellow at NCI he discovered that heterochromatic gene silencing can be stably propagated as epigenetic states through meiosis and inherited in cis. Grewal joined Cold Spring Harbor Laboratory faculty in 1998, where he uncovered a surprising connection between RNAi and heterochromatin assembly that was named “Breakthrough of the Year 2002” by Science. In 2003, Grewal returned to the NCI as a Senior Investigator and was appointed Chief of the Laboratory of Biochemistry and Molecular Biology in 2011. His work has elucidated how heterochromatin is assembled in different parts of the genome and revealed its diverse genome regulatory functions. Three of his papers are judged historic discoveries in the past 50 years by Nature. Grewal is the recipient of the Newcomb-Cleveland Prize, NIH Merit Award, and the NIH Directors’ award. In 2014, he was elected to the National Academy of Sciences and the American Academy of Arts and Sciences.
Research Interests
Papers共 75 篇Author StatisticsCo-AuthorSimilar Experts
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biorxiv(2024)
bioRxiv : the preprint server for biology (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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