基本信息
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Bio
My laboratory develops optical and histological methods for 3-D characterization of tissue microstructure, vasculature, and innervation. We prepare transparent specimens (e.g., mouse and human intestine, pancreas, liver, and kidney) with optical clearing to reveal the fluorescently labeled tissue architectures in space. Our ongoing work involves the integration of modern 3-D histology (fluorescence and transmitted light signals) and classic microtome-based histology (H&E and IHC signals) for multiplex human tissue analysis in health and disease.
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New in 2023: Antifade technology for 3-D/super-resolution imaging in high-n polymer
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Instead of using the high-n liquid (immersion-based tissue clearing), we now embed the fluorescently labeled tissue in the solid high-n polymer for antifade 3-D/super-resolution imaging. The solvent-free condition is specifically designed for robust clinical tissue analysis by avoiding O2 diffusion in the specimen to minimize photobleaching. The photo-polymerized/embedded tissue features a long shelf life for storage, transport, and repetitive fluorescence imaging.
Please visit www.3d-histology.com to see the high-resolution images and 1080pHD videos of our work.
Research Interests
Papers共 88 篇Author StatisticsCo-AuthorSimilar Experts
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Gastroenterologyno. 5 (2024): S-616-S-617
Zenodo (CERN European Organization for Nuclear Research)no. 2 (2024): E107-E123
British Journal of Cancerno. 7 (2024): 1-13
Fu-Ting Hsiao,Hung-Jen Chien,Ya-Hsien Chou,Shih-Jung Peng,Mei-Hsin Chung, Tzu-Hui Huang, Li-Wen Lo,Chia-Ning Shen,Hsiu-Pi Chang,Chih-Yuan Lee,Chien-Chia Chen,Yung-Ming Jeng,
Pharmacology & therapeutics (2023): 108521-108521
ADVANCED SCIENCEno. 36 (2023): n/a-n/a
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISMno. 4 (2022): E354-E365
FRONTIERS IN ENDOCRINOLOGY (2021): 644826-644826
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Author Statistics
#Papers: 88
#Citation: 1397
H-Index: 22
G-Index: 36
Sociability: 5
Diversity: 1
Activity: 0
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