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Dr. Yamanaka’s research focuses on ways to generate cells resembling embryonic stem cells by reprogramming somatic, or skin, cells. He seeks to understand the molecular mechanisms that underlie pluripotency and the rapid proliferation of embryonic stem cells—they can become any type of cell in the body—and to identify the factors that induce reprogramming.
Dr. Yamanaka’s discovery that adult somatic cells can be reprogrammed into pluripotent cells has had a profound effect on developmental and stem cell biology. By introducing the genes for four factors that turn genes on and off, he induced the skin cells of adult mice to become like embryonic stem cells, which he called induced pluripotent stem (iPS) cells. This iPS cell technology represents an entirely new platform for fundamental studies of developmental biology. Rather than using disease models made in yeast, flies, mice or other animals, iPS cells can be taken from patients with a specific disease. As a result, they contain a complete set of the genes that resulted in that disease—representing the potential of an almost perfect disease model for studying disease development, new drugs and treatments.
Dr. Yamanaka’s discovery that adult somatic cells can be reprogrammed into pluripotent cells has had a profound effect on developmental and stem cell biology. By introducing the genes for four factors that turn genes on and off, he induced the skin cells of adult mice to become like embryonic stem cells, which he called induced pluripotent stem (iPS) cells. This iPS cell technology represents an entirely new platform for fundamental studies of developmental biology. Rather than using disease models made in yeast, flies, mice or other animals, iPS cells can be taken from patients with a specific disease. As a result, they contain a complete set of the genes that resulted in that disease—representing the potential of an almost perfect disease model for studying disease development, new drugs and treatments.
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MOLECULAR PHARMACEUTICSno. 8 (2023): 4071-4085
Journal of Hypertensionno. Suppl 1 (2023): e4-e4
Developmental cellno. 16 (2023): 1477-1488.e5
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