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NAME
Shen, Wen-Jun
POSITION TITLE
Senior Research Scientist
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION DEGREE
(if applicable) YEAR(s) FIELD OF STUDY
University of London, London, UK
University of London
University of London
Baylor College of Medicine
Ph.D. 1991 Biochemistry, Mol Biol.
University College London, London, UK 1991-1993 Biochemistry, Mol Biol. BBiol.
Baylor College of Medicine, Houston, TX
1993-1996 Cell Biology
I have broad background in molecular and cell biology with specific training and expertise in key research areas in proteins/pathways for insulin secretion and lipid metabolism. Throughout my career as research scientist, I have worked on various components in controlling lipid droplet metabolism. These include lipases, lipid droplet associated proteins as well as their interacting proteins in adipose tissue, liver and steroidogenic tissue. I have also been working on mechanisms underlying the development of metabolic dyslipidemia and fatty liver diseases, and potential interventions/compounds for the treatment of metabolic dyslipidemia. Recent work also involves the exploration of lipid signals in controlling adipogenesis and osteoblastogenesis during aging, and shown that decreased adipogenesis by inhibiting HSL could aid in maintain high bone volume during aging process as well as promote bone regeneration.
I have hands-on experiences with many of the molecular and cellular biological systems including: FACS analyzing and sorting of cells from bone marrow, muscle, stromal vascular cells from adipose tissue, as well as tissue cultured cell lines. Microarray analysis of gene expression, sample preparation and data analysis for Mass spectrometry analysis of proteomics and lipid profiling, NextGen DNA sequencing sample preparation and data analysis, RNAseq sample preparation and data analysis. I have also experiences with confoco microacopy as well as in vivo analysis with animal models using DEXA, microCT and PET imagers.
A. Positions and Honors.
Positions and Employment
1988-1991 Graduate Student, Imperial College, University of London, London, UK
1991-1993 Postdoctoral Fellow, University College, London, UK
1993-1996 Postdoctoral Fellow, Baylor College of Medicine, Houston, TX
1996-2001 Research Associate, Stanford University
2001-present Senior Research Scientist, Department of Medicine, Stanford University
2002-present Senior Research Scientist, GRECC, VA Palo Alto Health Care System
2013-present Member of safety review committee at VA Palo Alto Health Care System
Other Experience and Professional Memberships
1999 American Diabetes Association
2000 American Heart Association
2011 Chair of session 2 at 8th International Conference of Functional Foods for Chronicle Diseases
2014 PRMRP FY14 IIRA Pre-application Reviewer
2015 CDMRP Ad Hoc Discovery Award Metabolic Disease (Ad-DIS-MD)
Honors
1988-1991 Scholarship for Ph.D. Study from the British Council, UK
1990 Travel Award from Society of Experimental Biology, UK
1991-1993 Medical Research Council Postdoctoral Research Fellow, UK
1993 Travel Award, Miami Winter Symposium, USA
1996 Corning Nichols Young Investigator's Award, 10th International Congress, Endocrinology
2000-2002 American Diabetes Association Research Award
B. Contribution to Science
1. Insulin secretion:
Early in my scientific career, I have worked on mechanisms controlling the human insulin receptor gene expression and have identified the cis-element responsible for Rb stimulation of human insulin receptor. We have localized the N-terminal domain of Rb to be important for this function. Multiple cis-acting elements have been defined to be important for the transcriptional regulation of the human insulin receptor (hIR) gene expression. Finally, the mechanism by which Rb activates the hIR promoter are presented. I have also worked on regulation of insulin secretion by lipid signals, and have shown that beta-cell isoform of HSL is involved in maintaining lipid homeostasis in islets and contributes to the proper control of glucose stimulated insulin secretion.
1. Shen WJ, Kim HS, Tsai SY. Stimulation of human insulin receptor gene expression by retinoblastoma gene product. J Biol Chem 1995; 270:20525-20529.
2. Shen WJ, Liang Y, Wang J, Harada K, Patel S, Michie SA, Osuga J, Ishibashi S, Kraemer FB. Regulation of hormone-sensitive lipase in islets. Diabetes Res Clin Pract. 2007 Jan;75(1):14-26
2. Lipid Droplet Metabolism:
I have worked almost 20 years on various components controlling lipid droplet metabolism. These include lipases, lipid droplet a
Research Interests
Papers共 145 篇Author StatisticsCo-AuthorSimilar Experts
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Biochimica et biophysica acta. Molecular basis of diseaseno. 11 (2022): 166506-166506
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