基本信息
浏览量:3
职业迁徙
个人简介
Transcriptional memory in mouse embryonic stem cells
Our lab studies how transcription is maintained and altered over time using the model system of mouse embryonic stem cells. Our research combines cutting-edge technologies including CRISPR/Cas9-mediated gene editing, genomics, and single molecule live-cell imaging to explore the mechanisms of transcriptional memory. One example of transcriptional memory that we examine is how transcription programs are maintained across the cell cycle.
Transcriptional memory through the cell cycle
Each cell type in an organism has a specific function that is tied to its identity. Cell identity is determined primarily by the specific set of genes that are active in that cell type while silencing the rest. More importantly, the cell type specific gene program must be maintained throughout the lifetime of the organism.
This type of ‘transcriptional memory’ is potentially compromised every time a cell divides. When cells divide to form new cells, the DNA is condensed and gene activity is mostly turned off. However, each dividing cell also has to ‘remember’ the program of genes that specifies its identity. After division, how do the new daughter cells ‘know’ which genes to turn on and which ones to keep off?
Our lab studies how transcription is maintained and altered over time using the model system of mouse embryonic stem cells. Our research combines cutting-edge technologies including CRISPR/Cas9-mediated gene editing, genomics, and single molecule live-cell imaging to explore the mechanisms of transcriptional memory. One example of transcriptional memory that we examine is how transcription programs are maintained across the cell cycle.
Transcriptional memory through the cell cycle
Each cell type in an organism has a specific function that is tied to its identity. Cell identity is determined primarily by the specific set of genes that are active in that cell type while silencing the rest. More importantly, the cell type specific gene program must be maintained throughout the lifetime of the organism.
This type of ‘transcriptional memory’ is potentially compromised every time a cell divides. When cells divide to form new cells, the DNA is condensed and gene activity is mostly turned off. However, each dividing cell also has to ‘remember’ the program of genes that specifies its identity. After division, how do the new daughter cells ‘know’ which genes to turn on and which ones to keep off?
研究兴趣
论文共 35 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
BIOCHEMICAL SOCIETY TRANSACTIONSno. 2 (2024): 821-830
James Z J Kwan, Thomas F Nguyen,Anuli C Uzozie,Marek A Budzynski,Jieying Cui,Joseph M C Lee,Filip Van Petegem,Philipp F Lange,Sheila S Teves
eLife (2023)
James Z. J. Kwan, Thomas F. Nguyen,Anuli C. Uzozie,Marek A. Budzynski,Jieying Cui,Joseph M. C. Lee,Filip Van Petegem,Philipp F. Lange,Sheila S. Teves
ELIFE (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Rachel M. Price,Marek A. Budzyński,Junzhou Shen, Jennifer E. Mitchell, James Z.J. Kwan,Sheila S. Teves
biorxiv(2022)
Homa Hamledari,Parisa Asghari,Farah Jayousi, Alejandro Aguirre,Yasaman Maaref,Tiffany Barszczewski, Terri Ser,Edwin Moore,Wyeth Wasserman,Ramon Klein Geltink,Sheila Teves,Glen F. Tibbits
FRONTIERS IN CARDIOVASCULAR MEDICINE (2022): 967659-967659
bioRxiv (Cold Spring Harbor Laboratory) (2021)
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn